Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population

Background: Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. In this study, we investigated the possible association of vitamin D levels and rs703842 in the CYP27B1 gene with MS. Methodology: We used blood samp...

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Main Authors: Muhsin Elmas, Mustafa Solak, Mehmet Yaman, Saliha Handan Yildiz, Mujgan Erdogan, Tulay Koken
Format: Article
Language:English
Published: Discover STM Publishing Ltd 2020-06-01
Series:Journal of Biochemical and Clinical Genetics
Subjects:
Online Access:http://www.ejmanager.com/fulltextpdf.php?mno=87872
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author Muhsin Elmas
Mustafa Solak
Mehmet Yaman
Saliha Handan Yildiz
Mujgan Erdogan
Tulay Koken
author_facet Muhsin Elmas
Mustafa Solak
Mehmet Yaman
Saliha Handan Yildiz
Mujgan Erdogan
Tulay Koken
author_sort Muhsin Elmas
collection DOAJ
description Background: Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. In this study, we investigated the possible association of vitamin D levels and rs703842 in the CYP27B1 gene with MS. Methodology: We used blood samples of 99 patients (65 female, 35 male) with an magnetic resonance imaging (MRI)-confirmed definitive diagnosis of MS and 99 controls (70 female, 29 male) between the ages of 18-55 years. We measured their vitamin D levels, isolated their DNA, and scanned rs703842 polymorphism in the CYP27B1 gene. Results: Rs703842 polymorphism in the CYP27B1 gene in humans was found as three different genotypes: CC, CT, and TT. Among them, CC genotype was found higher in the patient group and CT genotype was found higher in the control group. The statistical analysis showed that the probability of a C allele having an association with MS to be 1.5189 times of the probability of T allele. Also, the vitamin D levels in the patient group were detected lower than the control group. Conclusion: Low levels of vitamin D and low expression of CYP27B1 were found to have an association with MS. [JBCGenetics 2020; 3(1.000): 3-6]
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spelling doaj.art-384235be5f9b4635b0e160d3302cada42023-05-30T11:46:08ZengDiscover STM Publishing LtdJournal of Biochemical and Clinical Genetics1658-807X2020-06-01313610.24911/JBCGenetics/183-158209814487872Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish populationMuhsin Elmas0Mustafa Solak1Mehmet Yaman2Saliha Handan Yildiz3Mujgan Erdogan4Tulay Koken5Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey Department of Neurology, Afyon Kocatepe University, Western Anatolia, Turkey Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, Turkey Department of Medical Genetics, Afyonkarahisar Health Sciences University, Western Anatolia, TurkeyBackground: Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. In this study, we investigated the possible association of vitamin D levels and rs703842 in the CYP27B1 gene with MS. Methodology: We used blood samples of 99 patients (65 female, 35 male) with an magnetic resonance imaging (MRI)-confirmed definitive diagnosis of MS and 99 controls (70 female, 29 male) between the ages of 18-55 years. We measured their vitamin D levels, isolated their DNA, and scanned rs703842 polymorphism in the CYP27B1 gene. Results: Rs703842 polymorphism in the CYP27B1 gene in humans was found as three different genotypes: CC, CT, and TT. Among them, CC genotype was found higher in the patient group and CT genotype was found higher in the control group. The statistical analysis showed that the probability of a C allele having an association with MS to be 1.5189 times of the probability of T allele. Also, the vitamin D levels in the patient group were detected lower than the control group. Conclusion: Low levels of vitamin D and low expression of CYP27B1 were found to have an association with MS. [JBCGenetics 2020; 3(1.000): 3-6]http://www.ejmanager.com/fulltextpdf.php?mno=87872multiple sclerosisvitamin d25-hydroxyvitamin d3 1-alpha-hydroxylase
spellingShingle Muhsin Elmas
Mustafa Solak
Mehmet Yaman
Saliha Handan Yildiz
Mujgan Erdogan
Tulay Koken
Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population
Journal of Biochemical and Clinical Genetics
multiple sclerosis
vitamin d
25-hydroxyvitamin d3 1-alpha-hydroxylase
title Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population
title_full Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population
title_fullStr Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population
title_full_unstemmed Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population
title_short Association of vitamin D level and CYP27B1 gene polymorphism with multiple sclerosis in Turkish population
title_sort association of vitamin d level and cyp27b1 gene polymorphism with multiple sclerosis in turkish population
topic multiple sclerosis
vitamin d
25-hydroxyvitamin d3 1-alpha-hydroxylase
url http://www.ejmanager.com/fulltextpdf.php?mno=87872
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