Regulation of Immunity in Breast Cancer
Breast cancer affects millions of women worldwide, leading to many deaths and significant economic burden. Although there are numerous treatment options available, the huge potentials of immunotherapy in the management of localized and metastatic breast cancer is currently being explored. However, t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/8/1080 |
| _version_ | 1797728541442310144 |
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| author | Chidalu A. Edechi Nnamdi Ikeogu Jude E. Uzonna Yvonne Myal |
| author_facet | Chidalu A. Edechi Nnamdi Ikeogu Jude E. Uzonna Yvonne Myal |
| author_sort | Chidalu A. Edechi |
| collection | DOAJ |
| description | Breast cancer affects millions of women worldwide, leading to many deaths and significant economic burden. Although there are numerous treatment options available, the huge potentials of immunotherapy in the management of localized and metastatic breast cancer is currently being explored. However, there are significant gaps in understanding the complex interactions between the immune system and breast cancer. The immune system can be pro-tumorigenic and anti-tumorigenic depending on the cells involved and the conditions of the tumor microenvironment. In this review, we discuss current knowledge of breast cancer, including treatment options. We also give a brief overview of the immune system and comprehensively highlight the roles of different cells of the immune system in breast tumorigenesis, including recent research discoveries. Lastly, we discuss some immunotherapeutic strategies for the management of breast cancer. |
| first_indexed | 2024-03-12T11:15:32Z |
| format | Article |
| id | doaj.art-3842a13192a4460f85292561d7421d8c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T11:15:32Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3842a13192a4460f85292561d7421d8c2023-09-02T02:07:50ZengMDPI AGCancers2072-66942019-07-01118108010.3390/cancers11081080cancers11081080Regulation of Immunity in Breast CancerChidalu A. Edechi0Nnamdi Ikeogu1Jude E. Uzonna2Yvonne Myal3Department of Pathology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 3P5, CanadaDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0T5, CanadaDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0T5, CanadaDepartment of Pathology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 3P5, CanadaBreast cancer affects millions of women worldwide, leading to many deaths and significant economic burden. Although there are numerous treatment options available, the huge potentials of immunotherapy in the management of localized and metastatic breast cancer is currently being explored. However, there are significant gaps in understanding the complex interactions between the immune system and breast cancer. The immune system can be pro-tumorigenic and anti-tumorigenic depending on the cells involved and the conditions of the tumor microenvironment. In this review, we discuss current knowledge of breast cancer, including treatment options. We also give a brief overview of the immune system and comprehensively highlight the roles of different cells of the immune system in breast tumorigenesis, including recent research discoveries. Lastly, we discuss some immunotherapeutic strategies for the management of breast cancer.https://www.mdpi.com/2072-6694/11/8/1080breast cancerimmune responseimmunotherapyT and B cellsprolactin inducible protein |
| spellingShingle | Chidalu A. Edechi Nnamdi Ikeogu Jude E. Uzonna Yvonne Myal Regulation of Immunity in Breast Cancer Cancers breast cancer immune response immunotherapy T and B cells prolactin inducible protein |
| title | Regulation of Immunity in Breast Cancer |
| title_full | Regulation of Immunity in Breast Cancer |
| title_fullStr | Regulation of Immunity in Breast Cancer |
| title_full_unstemmed | Regulation of Immunity in Breast Cancer |
| title_short | Regulation of Immunity in Breast Cancer |
| title_sort | regulation of immunity in breast cancer |
| topic | breast cancer immune response immunotherapy T and B cells prolactin inducible protein |
| url | https://www.mdpi.com/2072-6694/11/8/1080 |
| work_keys_str_mv | AT chidaluaedechi regulationofimmunityinbreastcancer AT nnamdiikeogu regulationofimmunityinbreastcancer AT judeeuzonna regulationofimmunityinbreastcancer AT yvonnemyal regulationofimmunityinbreastcancer |