Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry
Forty‑one tumors were detected in a population of 1,649,003 cattle slaughtered in 4 abattoirs in Lombardy over a 5‑year period, for an overall prevalence of 2.5 tumors per 100,000 cattle. Tumors were classified according to the WHO histological classification of tumors of domestic animals. Alimenta...
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| Format: | Article |
| Language: | English |
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Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
2022-11-01
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| Series: | Veterinaria Italiana |
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| Online Access: | https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2421 |
| _version_ | 1811305996259164160 |
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| author | Andrea Cappelleri Lucia Minoli Claudio Pigoli Alessandro Costa Loris Zaghini Luca Bassanini Massimo Sinelli Marina Perri Mario Vittorio Luini Giovanna Tagliabue Lucia Rita Gibelli Eugenio Scanziani |
| author_facet | Andrea Cappelleri Lucia Minoli Claudio Pigoli Alessandro Costa Loris Zaghini Luca Bassanini Massimo Sinelli Marina Perri Mario Vittorio Luini Giovanna Tagliabue Lucia Rita Gibelli Eugenio Scanziani |
| author_sort | Andrea Cappelleri |
| collection | DOAJ |
| description |
Forty‑one tumors were detected in a population of 1,649,003 cattle slaughtered in 4 abattoirs in Lombardy over a 5‑year period, for an overall prevalence of 2.5 tumors per 100,000 cattle. Tumors were classified according to the WHO histological classification of tumors of domestic animals. Alimentary and hemopoietic systems were commonly affected with 9 cases each. Other affected sites were the respiratory (n = 3), urinary (n = 2), endocrine (n = 2), musculoskeletal (n = 2), nervous (n = 1), and cardiovascular (n = 1) systems. The peritoneum was affected by 6 cases, while the primary location of 3 tumors of the connective tissues and 3 metastatic carcinomas was unidentified. Liver tumors and mesotheliomas, for which environmental risk factors are well‑known in humans, were common, as well as tumors typically encountered in pediatric human patients (tumors of mesenchymal tissues, pulmonary blastomas and nephroblastomas). These findings suggest the useful role of bovines as sentinel and model for human carcinogenesis. Our study indicates that the establishment of a bovine cancer registry in Lombardy is feasible considering its potential contribution to understanding the role of environmental risk factors in the genesis of tumors in animals and humans.
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| first_indexed | 2024-04-13T08:36:29Z |
| format | Article |
| id | doaj.art-3842fb90563b4c0db7cff67cedcb9486 |
| institution | Directory Open Access Journal |
| issn | 0505-401X 1828-1427 |
| language | English |
| last_indexed | 2024-04-13T08:36:29Z |
| publishDate | 2022-11-01 |
| publisher | Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale |
| record_format | Article |
| series | Veterinaria Italiana |
| spelling | doaj.art-3842fb90563b4c0db7cff67cedcb94862022-12-22T02:54:05ZengIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. CaporaleVeterinaria Italiana0505-401X1828-14272022-11-0158110.12834/VetIt.2421.15367.1Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry Andrea Cappelleri0Lucia Minoli1Claudio Pigoli2Alessandro Costa3Loris Zaghini4Luca Bassanini5Massimo Sinelli6Marina Perri7Mario Vittorio Luini8Giovanna Tagliabue9Lucia Rita Gibelli10Eugenio Scanziani11Department of Veterinary Medicine, University of Milan, Lodi, Italy; Mouse and Animal Pathology Laboratory (MAPLab), Fondazione UniMi, Milan, ItalyDepartment of Veterinary Medicine, University of Milan, Lodi, Italy; Mouse and Animal Pathology Laboratory (MAPLab), Fondazione UniMi, Milan, ItalyLaboratorio di Istologia, Sede Territoriale di Milano, Dipartimento Area Territoriale Lombardia, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Via Giovanni Celoria 12, 20133 Milano, ItalyATS della Val Padana, Sede Territoriale di Mantova, ItalyATS della Val Padana, Sede Territoriale di Mantova, ItalyATS Città Metropolitana di Milano, Sede Territoriale di Lodi, ItalyATS Città Metropolitana di Milano, Sede Territoriale di Lodi, ItalyATS Città Metropolitana di Milano, Sede Territoriale di Lodi, ItalyIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia, ItalyCancer Registry Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia, ItalyDepartment of Veterinary Medicine, University of Milan, Lodi, Italy; Mouse and Animal Pathology Laboratory (MAPLab), Fondazione UniMi, Milan, Italy Forty‑one tumors were detected in a population of 1,649,003 cattle slaughtered in 4 abattoirs in Lombardy over a 5‑year period, for an overall prevalence of 2.5 tumors per 100,000 cattle. Tumors were classified according to the WHO histological classification of tumors of domestic animals. Alimentary and hemopoietic systems were commonly affected with 9 cases each. Other affected sites were the respiratory (n = 3), urinary (n = 2), endocrine (n = 2), musculoskeletal (n = 2), nervous (n = 1), and cardiovascular (n = 1) systems. The peritoneum was affected by 6 cases, while the primary location of 3 tumors of the connective tissues and 3 metastatic carcinomas was unidentified. Liver tumors and mesotheliomas, for which environmental risk factors are well‑known in humans, were common, as well as tumors typically encountered in pediatric human patients (tumors of mesenchymal tissues, pulmonary blastomas and nephroblastomas). These findings suggest the useful role of bovines as sentinel and model for human carcinogenesis. Our study indicates that the establishment of a bovine cancer registry in Lombardy is feasible considering its potential contribution to understanding the role of environmental risk factors in the genesis of tumors in animals and humans. https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2421AbattoirsCattleComparative oncologyNeoplasmsRegistriesRisk factors |
| spellingShingle | Andrea Cappelleri Lucia Minoli Claudio Pigoli Alessandro Costa Loris Zaghini Luca Bassanini Massimo Sinelli Marina Perri Mario Vittorio Luini Giovanna Tagliabue Lucia Rita Gibelli Eugenio Scanziani Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry Veterinaria Italiana Abattoirs Cattle Comparative oncology Neoplasms Registries Risk factors |
| title | Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry |
| title_full | Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry |
| title_fullStr | Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry |
| title_full_unstemmed | Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry |
| title_short | Retrospective study of tumors from cattle slaughtered in Lombardy (Italy): preliminary evaluation on the establishment of a bovine cancer registry |
| title_sort | retrospective study of tumors from cattle slaughtered in lombardy italy preliminary evaluation on the establishment of a bovine cancer registry |
| topic | Abattoirs Cattle Comparative oncology Neoplasms Registries Risk factors |
| url | https://www.veterinariaitaliana.izs.it/index.php/VetIt/article/view/2421 |
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