Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 cases
Abstract Background Although in vitro fertilization (IVF) can increase the incidence of hypertensive disorders of pregnancy (HDP), the pregnancy outcomes and disease phenotype of HDP in singleton pregnancies conceived via IVF remain unclear. Methods This retrospective cohort study enrolled 1130 sing...
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| Format: | Article |
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BMC
2023-07-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-023-05838-5 |
| _version_ | 1797773874546343936 |
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| author | Fen Dai Yehui Lan Shuangjia Pan Yuhuan Wang Ying Hua Wenya Xiao |
| author_facet | Fen Dai Yehui Lan Shuangjia Pan Yuhuan Wang Ying Hua Wenya Xiao |
| author_sort | Fen Dai |
| collection | DOAJ |
| description | Abstract Background Although in vitro fertilization (IVF) can increase the incidence of hypertensive disorders of pregnancy (HDP), the pregnancy outcomes and disease phenotype of HDP in singleton pregnancies conceived via IVF remain unclear. Methods This retrospective cohort study enrolled 1130 singleton pregnancies with HDP from 2016 to 2020. According to the mode of conception, they were allocated into IVF (n = 102) and natural conception (NC) groups (n = 1028). All IVF pregnancies were subdivided into frozen embryo transfer (FET) group (n = 42) and fresh embryo transfer (ET) group (n = 60). Demographic data, pregnancy outcomes and disease phenotypes of HDP among the groups were compared. The risk factors for severe preeclampsia (PE) and early-onset PE were analyzed. Results The incidences of early-onset PE (P<0.001), severe PE (P = 0.016), cesarean section (P<0.001) and preterm births (P = 0.003) in the IVF-HDP group were significantly higher than those in the NC-HDP group, and gestational age at diagnosis of HDP (P = 0.027) and gestational age at delivery (P = 0.004) were earlier and birthweight of the neonates (P = 0.033) were lower in the IVF group. In singleton pregnancies with HDP, IVF was associated with increased risks for both severe PE and early-onset PE (aOR 1.945, 95% CI 1.256, 3.014; and aOR 2.373, 95% CI 1.537, 3.663, respectively), as well as FET, family history of preeclampsia, intrahepatic cholestasis of pregnancy, gestational hypothyroidism and multiparity were associated with increased risks of severe PE and early-onset PE. Conclusions In singleton pregnancies with HDP, IVF was associated with an increased incidence of the disease phenotype (severe or early-onset PE), as well as an increased incidence of pregnancy outcomes related to severe PE and early-onset PE. |
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| id | doaj.art-3843c0ac7e544eb3913c3e3c8ea6c793 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-12T22:12:47Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-3843c0ac7e544eb3913c3e3c8ea6c7932023-07-23T11:29:10ZengBMCBMC Pregnancy and Childbirth1471-23932023-07-012311910.1186/s12884-023-05838-5Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 casesFen Dai0Yehui Lan1Shuangjia Pan2Yuhuan Wang3Ying Hua4Wenya Xiao5Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical UniversityAbstract Background Although in vitro fertilization (IVF) can increase the incidence of hypertensive disorders of pregnancy (HDP), the pregnancy outcomes and disease phenotype of HDP in singleton pregnancies conceived via IVF remain unclear. Methods This retrospective cohort study enrolled 1130 singleton pregnancies with HDP from 2016 to 2020. According to the mode of conception, they were allocated into IVF (n = 102) and natural conception (NC) groups (n = 1028). All IVF pregnancies were subdivided into frozen embryo transfer (FET) group (n = 42) and fresh embryo transfer (ET) group (n = 60). Demographic data, pregnancy outcomes and disease phenotypes of HDP among the groups were compared. The risk factors for severe preeclampsia (PE) and early-onset PE were analyzed. Results The incidences of early-onset PE (P<0.001), severe PE (P = 0.016), cesarean section (P<0.001) and preterm births (P = 0.003) in the IVF-HDP group were significantly higher than those in the NC-HDP group, and gestational age at diagnosis of HDP (P = 0.027) and gestational age at delivery (P = 0.004) were earlier and birthweight of the neonates (P = 0.033) were lower in the IVF group. In singleton pregnancies with HDP, IVF was associated with increased risks for both severe PE and early-onset PE (aOR 1.945, 95% CI 1.256, 3.014; and aOR 2.373, 95% CI 1.537, 3.663, respectively), as well as FET, family history of preeclampsia, intrahepatic cholestasis of pregnancy, gestational hypothyroidism and multiparity were associated with increased risks of severe PE and early-onset PE. Conclusions In singleton pregnancies with HDP, IVF was associated with an increased incidence of the disease phenotype (severe or early-onset PE), as well as an increased incidence of pregnancy outcomes related to severe PE and early-onset PE.https://doi.org/10.1186/s12884-023-05838-5In vitro fertilizationHypertensive disorders of pregnancySevere preeclampsiaEarly-onset preeclampsia |
| spellingShingle | Fen Dai Yehui Lan Shuangjia Pan Yuhuan Wang Ying Hua Wenya Xiao Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 cases BMC Pregnancy and Childbirth In vitro fertilization Hypertensive disorders of pregnancy Severe preeclampsia Early-onset preeclampsia |
| title | Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 cases |
| title_full | Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 cases |
| title_fullStr | Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 cases |
| title_full_unstemmed | Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 cases |
| title_short | Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 cases |
| title_sort | pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization a retrospective analysis of 1130 cases |
| topic | In vitro fertilization Hypertensive disorders of pregnancy Severe preeclampsia Early-onset preeclampsia |
| url | https://doi.org/10.1186/s12884-023-05838-5 |
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