Outbreak of Influenza and Other Respiratory Viruses in Hospitalized Patients Alongside the SARS-CoV-2 Pandemic
Influenza A and other respiratory viruses, circulate each winter and cause respiratory illness that can lead to severe complications in hospitalized patients. During the COVID-19 pandemic, only a few cases of respiratory viruses were detected in Israel. Our study applied RT-PCR to examine 13,674 sam...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.902476/full |
| _version_ | 1828805522818596864 |
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| author | Ilana S. Fratty Ilana S. Fratty Shira Reznik-Balter Ital Nemet Nofar Atari Limor Kliker Limor Kliker Hilda Sherbany Nathan Keller Nathan Keller Michal Stein Ella Mendelson Ella Mendelson Michal Mandelboim Michal Mandelboim |
| author_facet | Ilana S. Fratty Ilana S. Fratty Shira Reznik-Balter Ital Nemet Nofar Atari Limor Kliker Limor Kliker Hilda Sherbany Nathan Keller Nathan Keller Michal Stein Ella Mendelson Ella Mendelson Michal Mandelboim Michal Mandelboim |
| author_sort | Ilana S. Fratty |
| collection | DOAJ |
| description | Influenza A and other respiratory viruses, circulate each winter and cause respiratory illness that can lead to severe complications in hospitalized patients. During the COVID-19 pandemic, only a few cases of respiratory viruses were detected in Israel. Our study applied RT-PCR to examine 13,674 samples collected from patients hospitalized with respiratory symptoms in 2019, 2020, and 2021 and the first half of the 2022 winter. A sharp increase in influenza A(H3N2) cases was observed in winter 2021-2022 as compared to 2020, followed by a sudden decrease in influenza cases after the detection of the SARS-CoV-2 omicron variant in Israel. Comparison of the area under the curve (AUC) of influenza infection rates during 7 consecutive winter seasons found that the minimal AUC between 2015 and 2020 was 281.1, while in 2021-2022, it was significantly lower (162.6 AUC; p = 0.0017), although the percentage of positive influenza cases was similar to those of previous years. The presented findings show how the dominance of influenza A(H3N2) abruptly ended upon circulation of the SARS-CoV-2 omicron variant. However, a post-COVID-19 influenza outbreak is possible, hence the planning of the next influenza vaccine is critical to ensure lower influenza-related hospitalization rates. |
| first_indexed | 2024-12-12T07:56:39Z |
| format | Article |
| id | doaj.art-384634011fd34b388b402e4d38a5f304 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T07:56:39Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-384634011fd34b388b402e4d38a5f3042022-12-22T00:32:17ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-06-011310.3389/fmicb.2022.902476902476Outbreak of Influenza and Other Respiratory Viruses in Hospitalized Patients Alongside the SARS-CoV-2 PandemicIlana S. Fratty0Ilana S. Fratty1Shira Reznik-Balter2Ital Nemet3Nofar Atari4Limor Kliker5Limor Kliker6Hilda Sherbany7Nathan Keller8Nathan Keller9Michal Stein10Ella Mendelson11Ella Mendelson12Michal Mandelboim13Michal Mandelboim14Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat Gan, IsraelThe Israel Center for Disease Control, Israel Ministry of Health, Ramat Gan, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat Gan, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat Gan, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat Gan, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat Gan, IsraelSackler Faculty of Medicine, Department of Epidemiology and Preventive Medicine, Tel Aviv University, Tel Aviv, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat Gan, IsraelSchool of Health Sciences, Ariel University, Ariel, IsraelPediatric Infectious Disease Unit, Sheba Medical Center, Ramat Gan, IsraelPediatric Infectious Disease Unit, Sheba Medical Center, Ramat Gan, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat Gan, IsraelSackler Faculty of Medicine, Department of Epidemiology and Preventive Medicine, Tel Aviv University, Tel Aviv, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat Gan, IsraelSackler Faculty of Medicine, Department of Epidemiology and Preventive Medicine, Tel Aviv University, Tel Aviv, IsraelInfluenza A and other respiratory viruses, circulate each winter and cause respiratory illness that can lead to severe complications in hospitalized patients. During the COVID-19 pandemic, only a few cases of respiratory viruses were detected in Israel. Our study applied RT-PCR to examine 13,674 samples collected from patients hospitalized with respiratory symptoms in 2019, 2020, and 2021 and the first half of the 2022 winter. A sharp increase in influenza A(H3N2) cases was observed in winter 2021-2022 as compared to 2020, followed by a sudden decrease in influenza cases after the detection of the SARS-CoV-2 omicron variant in Israel. Comparison of the area under the curve (AUC) of influenza infection rates during 7 consecutive winter seasons found that the minimal AUC between 2015 and 2020 was 281.1, while in 2021-2022, it was significantly lower (162.6 AUC; p = 0.0017), although the percentage of positive influenza cases was similar to those of previous years. The presented findings show how the dominance of influenza A(H3N2) abruptly ended upon circulation of the SARS-CoV-2 omicron variant. However, a post-COVID-19 influenza outbreak is possible, hence the planning of the next influenza vaccine is critical to ensure lower influenza-related hospitalization rates.https://www.frontiersin.org/articles/10.3389/fmicb.2022.902476/fullrespiratory virusesinfluenzaoutbreakSARS-CoV-2omicron variant |
| spellingShingle | Ilana S. Fratty Ilana S. Fratty Shira Reznik-Balter Ital Nemet Nofar Atari Limor Kliker Limor Kliker Hilda Sherbany Nathan Keller Nathan Keller Michal Stein Ella Mendelson Ella Mendelson Michal Mandelboim Michal Mandelboim Outbreak of Influenza and Other Respiratory Viruses in Hospitalized Patients Alongside the SARS-CoV-2 Pandemic Frontiers in Microbiology respiratory viruses influenza outbreak SARS-CoV-2 omicron variant |
| title | Outbreak of Influenza and Other Respiratory Viruses in Hospitalized Patients Alongside the SARS-CoV-2 Pandemic |
| title_full | Outbreak of Influenza and Other Respiratory Viruses in Hospitalized Patients Alongside the SARS-CoV-2 Pandemic |
| title_fullStr | Outbreak of Influenza and Other Respiratory Viruses in Hospitalized Patients Alongside the SARS-CoV-2 Pandemic |
| title_full_unstemmed | Outbreak of Influenza and Other Respiratory Viruses in Hospitalized Patients Alongside the SARS-CoV-2 Pandemic |
| title_short | Outbreak of Influenza and Other Respiratory Viruses in Hospitalized Patients Alongside the SARS-CoV-2 Pandemic |
| title_sort | outbreak of influenza and other respiratory viruses in hospitalized patients alongside the sars cov 2 pandemic |
| topic | respiratory viruses influenza outbreak SARS-CoV-2 omicron variant |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.902476/full |
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