The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050484/full |
| _version_ | 1811220844882427904 |
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| author | María Luisa Sánchez-León María Luisa Sánchez-León Carlos Jiménez-Cortegana Carlos Jiménez-Cortegana Gabriel Cabrera Elba Mónica Vermeulen Luis de la Cruz-Merino Victor Sánchez-Margalet Victor Sánchez-Margalet |
| author_facet | María Luisa Sánchez-León María Luisa Sánchez-León Carlos Jiménez-Cortegana Carlos Jiménez-Cortegana Gabriel Cabrera Elba Mónica Vermeulen Luis de la Cruz-Merino Victor Sánchez-Margalet Victor Sánchez-Margalet |
| author_sort | María Luisa Sánchez-León |
| collection | DOAJ |
| description | Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumor microenvironment (TME), where myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells known to play a key role in tumor immunoevasion by inhibiting T-cell responses, are extremely accumulated. In addition, it has been demonstrated that MDSCs not only suppress DC functions, but also their maturation and development within the myeloid linage. Considering that an increased number of DCs as well as the improvement in their functions boost antitumor immunity, DC-based vaccines were developed two decades ago, and promising results have been obtained throughout these years. Therefore, the remodeling of the TME promoted by DC vaccination has also been explored. Here, we aim to review the effectiveness of different DCs-based vaccines in murine models and cancer patients, either alone or synergistically combined with other treatments, being especially focused on their effect on the MDSC population. |
| first_indexed | 2024-04-12T07:49:51Z |
| format | Article |
| id | doaj.art-384720ac6386477b803ea8f2bcb33a17 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T07:49:51Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-384720ac6386477b803ea8f2bcb33a172022-12-22T03:41:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10504841050484The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cellsMaría Luisa Sánchez-León0María Luisa Sánchez-León1Carlos Jiménez-Cortegana2Carlos Jiménez-Cortegana3Gabriel Cabrera4Elba Mónica Vermeulen5Luis de la Cruz-Merino6Victor Sánchez-Margalet7Victor Sánchez-Margalet8Department of Medical Biochemistry and Molecular Biology, School of Medicine, University of Seville, Seville, SpainMedical Oncology Service, Virgen Macarena University Hospital, Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, University of Seville, Seville, SpainDepartment of Laboratory Medicine, Virgen Macarena University Hospital, Seville, SpainLaboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe capital, ArgentinaLaboratorio de Células Presentadoras de Antígeno y Respuesta Inflamatoria, Instituto de Medicina Experimental (IMEX) - CONICET, Academia Nacional de Medicina, Buenos Aires, ArgentinaMedical Oncology Service, Virgen Macarena University Hospital, Seville, SpainDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, University of Seville, Seville, SpainDepartment of Laboratory Medicine, Virgen Macarena University Hospital, Seville, SpainDendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumor microenvironment (TME), where myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells known to play a key role in tumor immunoevasion by inhibiting T-cell responses, are extremely accumulated. In addition, it has been demonstrated that MDSCs not only suppress DC functions, but also their maturation and development within the myeloid linage. Considering that an increased number of DCs as well as the improvement in their functions boost antitumor immunity, DC-based vaccines were developed two decades ago, and promising results have been obtained throughout these years. Therefore, the remodeling of the TME promoted by DC vaccination has also been explored. Here, we aim to review the effectiveness of different DCs-based vaccines in murine models and cancer patients, either alone or synergistically combined with other treatments, being especially focused on their effect on the MDSC population.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050484/fulldendritic cellsmyeloid-derived suppressor cellsvaccinescancerimmunosuppression |
| spellingShingle | María Luisa Sánchez-León María Luisa Sánchez-León Carlos Jiménez-Cortegana Carlos Jiménez-Cortegana Gabriel Cabrera Elba Mónica Vermeulen Luis de la Cruz-Merino Victor Sánchez-Margalet Victor Sánchez-Margalet The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells Frontiers in Immunology dendritic cells myeloid-derived suppressor cells vaccines cancer immunosuppression |
| title | The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells |
| title_full | The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells |
| title_fullStr | The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells |
| title_full_unstemmed | The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells |
| title_short | The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells |
| title_sort | effects of dendritic cell based vaccines in the tumor microenvironment impact on myeloid derived suppressor cells |
| topic | dendritic cells myeloid-derived suppressor cells vaccines cancer immunosuppression |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050484/full |
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