The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells

The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells

Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumo...

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Bibliographic Details
Main Authors: María Luisa Sánchez-León, Carlos Jiménez-Cortegana, Gabriel Cabrera, Elba Mónica Vermeulen, Luis de la Cruz-Merino, Victor Sánchez-Margalet
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
myeloid-derived suppressor cells
vaccines
cancer
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050484/full

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