Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis
Abstract Purpose To compare the effect of vancomycin presoak treatment of grafts during anterior cruciate ligament reconstruction on the incidence of postoperative infection or septic arthritis. Methods Studies published before May 3, 2022 investigating vancomycin presoak of grafts during anterior c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-023-06331-y |
| _version_ | 1797850220715835392 |
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| author | Mingwei Hu Yifan Zhang Guangqian Shang Jianjun Guo Hao Xu Xue Ma Xue Yang Shuai Xiang |
| author_facet | Mingwei Hu Yifan Zhang Guangqian Shang Jianjun Guo Hao Xu Xue Ma Xue Yang Shuai Xiang |
| author_sort | Mingwei Hu |
| collection | DOAJ |
| description | Abstract Purpose To compare the effect of vancomycin presoak treatment of grafts during anterior cruciate ligament reconstruction on the incidence of postoperative infection or septic arthritis. Methods Studies published before May 3, 2022 investigating vancomycin presoak of grafts during anterior cruciate ligament reconstruction were searched in the PubMed and Cochrane Central Register of Controlled Trials. Studies were screened, and data on the incidence of postoperative infection or septic arthritis were extracted and included in the analysis. Results Thirteen studies were included for analysis after search screening, yielding a total of 31,150 participants for analysis, of whom 11,437 received graft vancomycin presoak treatment, and 19,713 did not receive treatment. Participants who received vancomycin treatment had significantly lower infection rates (0.09% versus 0.74%; OR 0.17; 95% CI 0.10, 0.30; P < 0.00001). Conclusion Pre-soaking of the graft with vancomycin during ACL reconstruction reduced the incidence of postoperative infection and septic arthritis. |
| first_indexed | 2024-04-09T18:56:54Z |
| format | Article |
| id | doaj.art-38487329a0074da8a814bec388abd0e8 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-09T18:56:54Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-38487329a0074da8a814bec388abd0e82023-04-09T11:06:12ZengBMCBMC Musculoskeletal Disorders1471-24742023-04-012411810.1186/s12891-023-06331-yVancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysisMingwei Hu0Yifan Zhang1Guangqian Shang2Jianjun Guo3Hao Xu4Xue Ma5Xue Yang6Shuai Xiang7Department of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityOperation Room, The Affiliated Hospital of Qingdao UniversityDepartment of Joint Surgery, The Affiliated Hospital of Qingdao UniversityAbstract Purpose To compare the effect of vancomycin presoak treatment of grafts during anterior cruciate ligament reconstruction on the incidence of postoperative infection or septic arthritis. Methods Studies published before May 3, 2022 investigating vancomycin presoak of grafts during anterior cruciate ligament reconstruction were searched in the PubMed and Cochrane Central Register of Controlled Trials. Studies were screened, and data on the incidence of postoperative infection or septic arthritis were extracted and included in the analysis. Results Thirteen studies were included for analysis after search screening, yielding a total of 31,150 participants for analysis, of whom 11,437 received graft vancomycin presoak treatment, and 19,713 did not receive treatment. Participants who received vancomycin treatment had significantly lower infection rates (0.09% versus 0.74%; OR 0.17; 95% CI 0.10, 0.30; P < 0.00001). Conclusion Pre-soaking of the graft with vancomycin during ACL reconstruction reduced the incidence of postoperative infection and septic arthritis.https://doi.org/10.1186/s12891-023-06331-yAnterior cruciate ligament reconstructionvancomycinInfectionAntibioticSports medicine |
| spellingShingle | Mingwei Hu Yifan Zhang Guangqian Shang Jianjun Guo Hao Xu Xue Ma Xue Yang Shuai Xiang Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis BMC Musculoskeletal Disorders Anterior cruciate ligament reconstruction vancomycin Infection Antibiotic Sports medicine |
| title | Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis |
| title_full | Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis |
| title_fullStr | Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis |
| title_full_unstemmed | Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis |
| title_short | Vancomycin presoak reduces infection in anterior cruciate ligament reconstruction: a systematic review and meta-analysis |
| title_sort | vancomycin presoak reduces infection in anterior cruciate ligament reconstruction a systematic review and meta analysis |
| topic | Anterior cruciate ligament reconstruction vancomycin Infection Antibiotic Sports medicine |
| url | https://doi.org/10.1186/s12891-023-06331-y |
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