Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation

Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation

Summary: Transient receptor potential canonical type 6 (TRPC6) is a non-voltage-gated channel that principally conducts calcium. Elevated channel activation contributes to fibrosis, hypertrophy, and proteinuria, often coupled to stimulation of nuclear factor of activated T-cells (NFAT). TRPC6 is pos...

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Bibliographic Details
Main Authors: Sumita Mishra, Junfeng Ma, Desirae McKoy, Masayuki Sasaki, Federica Farinelli, Richard C. Page, Mark J. Ranek, Natasha Zachara, David A. Kass
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Biochemistry
Cellular physiology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223003711

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