Identification of Biomarkers for Prostate Cancer
BACKGROUND: Prostate cancer (PCa) was the second most common type of cancer and the fifth leading cause of cancer-related death in men. The great challenge for physicians is being able to accurately predict PCa prognosis and treatment response in order to reduce PCa-speciic mortality while avoiding...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Secretariat of The Indonesian Biomedical Journal
2014-12-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | http://inabj.org/index.php/ibj/article/view/26 |
| _version_ | 1819157039524347904 |
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| author | Anna Meiliana Andi Wijaya |
| author_facet | Anna Meiliana Andi Wijaya |
| author_sort | Anna Meiliana |
| collection | DOAJ |
| description | BACKGROUND: Prostate cancer (PCa) was the second most common type of cancer and the fifth leading cause of cancer-related death in men. The great challenge for physicians is being able to accurately predict PCa prognosis and treatment response in order to reduce PCa-speciic mortality while avoiding overtreatment by identifying of when to intervene, and in which patients. CONTENT: Currently, PCa prognosis and treatment decision of PCa involved digital rectal examination, Prostate-Speciic Antigens (PSA), and subsequent biopsies for histopathological staging, known as Gleason score. However, each procedure has its shortcomings. Efforts to find a better clinically meaningful and non-invasive biomarkers still developed involving proteins, circulating tumor cells, nucleic acids, and the ‘omics' approaches. SUMMARY: Biomarkers for PCa will most likely be an assay employing multiple biomarkers in combination using protein and gene microarrays, containing markers that are differentially expressed in PCa. KEYWORDS: prostate cancer, PSA, biomarkers, nomograms, miRNA, proteomic, genomic, metabolomic. |
| first_indexed | 2024-12-22T16:02:26Z |
| format | Article |
| id | doaj.art-384c24920d1f4e6ba826ce068c0f2972 |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-12-22T16:02:26Z |
| publishDate | 2014-12-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-384c24920d1f4e6ba826ce068c0f29722022-12-21T18:20:40ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792014-12-01631233610.18585/inabj.v6i3.2617Identification of Biomarkers for Prostate CancerAnna Meiliana0Andi Wijaya1Postgraduate Program in Clinical Pharmacy, Padjadjaran University Jl. Eijkman No.38, BandungProdia Clinical Laboratory Jl. Cisangkuy No.2, BandungBACKGROUND: Prostate cancer (PCa) was the second most common type of cancer and the fifth leading cause of cancer-related death in men. The great challenge for physicians is being able to accurately predict PCa prognosis and treatment response in order to reduce PCa-speciic mortality while avoiding overtreatment by identifying of when to intervene, and in which patients. CONTENT: Currently, PCa prognosis and treatment decision of PCa involved digital rectal examination, Prostate-Speciic Antigens (PSA), and subsequent biopsies for histopathological staging, known as Gleason score. However, each procedure has its shortcomings. Efforts to find a better clinically meaningful and non-invasive biomarkers still developed involving proteins, circulating tumor cells, nucleic acids, and the ‘omics' approaches. SUMMARY: Biomarkers for PCa will most likely be an assay employing multiple biomarkers in combination using protein and gene microarrays, containing markers that are differentially expressed in PCa. KEYWORDS: prostate cancer, PSA, biomarkers, nomograms, miRNA, proteomic, genomic, metabolomic.http://inabj.org/index.php/ibj/article/view/26 |
| spellingShingle | Anna Meiliana Andi Wijaya Identification of Biomarkers for Prostate Cancer Indonesian Biomedical Journal |
| title | Identification of Biomarkers for Prostate Cancer |
| title_full | Identification of Biomarkers for Prostate Cancer |
| title_fullStr | Identification of Biomarkers for Prostate Cancer |
| title_full_unstemmed | Identification of Biomarkers for Prostate Cancer |
| title_short | Identification of Biomarkers for Prostate Cancer |
| title_sort | identification of biomarkers for prostate cancer |
| url | http://inabj.org/index.php/ibj/article/view/26 |
| work_keys_str_mv | AT annameiliana identificationofbiomarkersforprostatecancer AT andiwijaya identificationofbiomarkersforprostatecancer |