Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study
Adolescence is characterized by dynamic neurodevelopment, which poses opportunities for risk and resilience. Adverse childhood experiences (ACEs) confer additional risk to the developing brain, where ACEs have been associated with alterations in functional magnetic resonance imaging (fMRI) BOLD sign...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929324000392 |
| _version_ | 1797203016191836160 |
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| author | Elizabeth A. Stinson Ryan M. Sullivan Gabriella Y. Navarro Alexander L. Wallace Christine L. Larson Krista M. Lisdahl |
| author_facet | Elizabeth A. Stinson Ryan M. Sullivan Gabriella Y. Navarro Alexander L. Wallace Christine L. Larson Krista M. Lisdahl |
| author_sort | Elizabeth A. Stinson |
| collection | DOAJ |
| description | Adolescence is characterized by dynamic neurodevelopment, which poses opportunities for risk and resilience. Adverse childhood experiences (ACEs) confer additional risk to the developing brain, where ACEs have been associated with alterations in functional magnetic resonance imaging (fMRI) BOLD signaling in brain regions underlying inhibitory control. Socioenvironmental factors like the family environment may amplify or buffer against the neurodevelopmental risks associated with ACEs. Using baseline to Year 2 follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, the current study examined how ACEs relate to fMRI BOLD signaling during successful inhibition on the Stop Signal Task in regions associated with inhibitory control and examined whether family conflict levels moderated that relationship. Results showed that greater ACEs were associated with reduced BOLD response in the right opercular region of the inferior frontal gyrus and bilaterally in the pre-supplementary motor area, which are key regions underlying inhibitory control. Further, greater BOLD response was correlated with less impulsivity behaviorally, suggesting reduced activation may not be behaviorally adaptive at this age. No significant two or three-way interactions with family conflict levels or time were found. Findings highlight the continued utility of examining the relationship between ACEs and neurodevelopmental outcomes and the importance of intervention/prevention of ACES. |
| first_indexed | 2024-04-24T08:12:37Z |
| format | Article |
| id | doaj.art-384da3ab530447d3bb7ff740dfd72b6b |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-04-24T08:12:37Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-384da3ab530447d3bb7ff740dfd72b6b2024-04-17T04:49:05ZengElsevierDevelopmental Cognitive Neuroscience1878-92932024-06-0167101378Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD studyElizabeth A. Stinson0Ryan M. Sullivan1Gabriella Y. Navarro2Alexander L. Wallace3Christine L. Larson4Krista M. Lisdahl5Department of Psychology, University of Wisconsin at Milwaukee, Milwaukee, WI 53201, United StatesDepartment of Psychology, University of Wisconsin at Milwaukee, Milwaukee, WI 53201, United StatesDepartment of Psychology, University of Wisconsin at Milwaukee, Milwaukee, WI 53201, United StatesDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, United StatesDepartment of Psychology, University of Wisconsin at Milwaukee, Milwaukee, WI 53201, United StatesDepartment of Psychology, University of Wisconsin at Milwaukee, Milwaukee, WI 53201, United States; Correspondence to: Department of Psychology, University of Wisconsin-Milwaukee, 2441 East Hartford Ave, Milwaukee, WI 53211, United States.Adolescence is characterized by dynamic neurodevelopment, which poses opportunities for risk and resilience. Adverse childhood experiences (ACEs) confer additional risk to the developing brain, where ACEs have been associated with alterations in functional magnetic resonance imaging (fMRI) BOLD signaling in brain regions underlying inhibitory control. Socioenvironmental factors like the family environment may amplify or buffer against the neurodevelopmental risks associated with ACEs. Using baseline to Year 2 follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, the current study examined how ACEs relate to fMRI BOLD signaling during successful inhibition on the Stop Signal Task in regions associated with inhibitory control and examined whether family conflict levels moderated that relationship. Results showed that greater ACEs were associated with reduced BOLD response in the right opercular region of the inferior frontal gyrus and bilaterally in the pre-supplementary motor area, which are key regions underlying inhibitory control. Further, greater BOLD response was correlated with less impulsivity behaviorally, suggesting reduced activation may not be behaviorally adaptive at this age. No significant two or three-way interactions with family conflict levels or time were found. Findings highlight the continued utility of examining the relationship between ACEs and neurodevelopmental outcomes and the importance of intervention/prevention of ACES.http://www.sciencedirect.com/science/article/pii/S1878929324000392Adverse childhood experiencesAdolescenceFamily environmentFunctional magnetic resonance imagingInhibitory control |
| spellingShingle | Elizabeth A. Stinson Ryan M. Sullivan Gabriella Y. Navarro Alexander L. Wallace Christine L. Larson Krista M. Lisdahl Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study Developmental Cognitive Neuroscience Adverse childhood experiences Adolescence Family environment Functional magnetic resonance imaging Inhibitory control |
| title | Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study |
| title_full | Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study |
| title_fullStr | Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study |
| title_full_unstemmed | Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study |
| title_short | Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study |
| title_sort | childhood adversity is associated with reduced bold response in inhibitory control regions amongst preadolescents from the abcd study |
| topic | Adverse childhood experiences Adolescence Family environment Functional magnetic resonance imaging Inhibitory control |
| url | http://www.sciencedirect.com/science/article/pii/S1878929324000392 |
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