Statin use and risk of cancer: An umbrella meta-analysis
BACKGROUND: The relationship between statin use and cancer risk has been debated for a long time. Physiologically plausible theories suggest that statins may lower the risk of cancer. We have updated the overview of meta-analyses to include up-to-date information, additional subgroup analyses, and s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Annals of Oncology Research and Therapy |
| Subjects: | |
| Online Access: | http://www.aort.info/article.asp?issn=2772-8382;year=2023;volume=3;issue=1;spage=14;epage=31;aulast=Kasana |
| _version_ | 1827295148305809408 |
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| author | Ruby Kasana Christy Thomas Gaurav Das Munlima Hazarika Krishna Undela |
| author_facet | Ruby Kasana Christy Thomas Gaurav Das Munlima Hazarika Krishna Undela |
| author_sort | Ruby Kasana |
| collection | DOAJ |
| description | BACKGROUND: The relationship between statin use and cancer risk has been debated for a long time. Physiologically plausible theories suggest that statins may lower the risk of cancer. We have updated the overview of meta-analyses to include up-to-date information, additional subgroup analyses, and site-specific cancer risk estimates.
MATERIALS AND METHODS: A systematic search was performed in the PubMed, Cochrane and Google scholar databases between June 2016 and December 2022. The search strategy included both statin- and cancer-related keywords. Meta-analyses examining the association between statin use and site-specific cancer risk were included. Two reviewers independently screened the literature, extracted data, and assessed the study quality using A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR 2) tool.
RESULTS: This up-to-date overview included 71 meta-analyses (33 new and 38 from the previous overview) of 14 site-specific cancers. Out of which, 29 (44%) meta-analyses had a “Critically low” and three reviews (5%) had a “High” quality of evidence with AMSTAR 2. The pooled results of meta-analyses showed that statins reduce the likelihood of biliary tract (33%), colorectal (9%), gastric (29%), gynecological (12%), hematological (19%), liver (42%), esophageal (19%), and pancreatic (18%) cancers. However, no association was identified between statin use and the risk of bladder, breast, kidney, lung, prostate, and skin cancers.
CONCLUSIONS: Statins may play a crucial role in cancer chemoprevention, reduce the risk of site-specific malignancies, and can be used as an adjuvant. |
| first_indexed | 2024-03-07T21:36:22Z |
| format | Article |
| id | doaj.art-384fa3e4e2b4405bb93da68fbc3f9f5f |
| institution | Directory Open Access Journal |
| issn | 2772-8382 2772-8390 |
| language | English |
| last_indexed | 2024-04-24T14:14:55Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Oncology Research and Therapy |
| spelling | doaj.art-384fa3e4e2b4405bb93da68fbc3f9f5f2024-04-03T08:46:57ZengWolters Kluwer Medknow PublicationsAnnals of Oncology Research and Therapy2772-83822772-83902023-01-0131143110.4103/aort.aort_34_22Statin use and risk of cancer: An umbrella meta-analysisRuby KasanaChristy ThomasGaurav DasMunlima HazarikaKrishna UndelaBACKGROUND: The relationship between statin use and cancer risk has been debated for a long time. Physiologically plausible theories suggest that statins may lower the risk of cancer. We have updated the overview of meta-analyses to include up-to-date information, additional subgroup analyses, and site-specific cancer risk estimates. MATERIALS AND METHODS: A systematic search was performed in the PubMed, Cochrane and Google scholar databases between June 2016 and December 2022. The search strategy included both statin- and cancer-related keywords. Meta-analyses examining the association between statin use and site-specific cancer risk were included. Two reviewers independently screened the literature, extracted data, and assessed the study quality using A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR 2) tool. RESULTS: This up-to-date overview included 71 meta-analyses (33 new and 38 from the previous overview) of 14 site-specific cancers. Out of which, 29 (44%) meta-analyses had a “Critically low” and three reviews (5%) had a “High” quality of evidence with AMSTAR 2. The pooled results of meta-analyses showed that statins reduce the likelihood of biliary tract (33%), colorectal (9%), gastric (29%), gynecological (12%), hematological (19%), liver (42%), esophageal (19%), and pancreatic (18%) cancers. However, no association was identified between statin use and the risk of bladder, breast, kidney, lung, prostate, and skin cancers. CONCLUSIONS: Statins may play a crucial role in cancer chemoprevention, reduce the risk of site-specific malignancies, and can be used as an adjuvant.http://www.aort.info/article.asp?issn=2772-8382;year=2023;volume=3;issue=1;spage=14;epage=31;aulast=Kasanacancerstatinumbrella meta-analysis |
| spellingShingle | Ruby Kasana Christy Thomas Gaurav Das Munlima Hazarika Krishna Undela Statin use and risk of cancer: An umbrella meta-analysis Annals of Oncology Research and Therapy cancer statin umbrella meta-analysis |
| title | Statin use and risk of cancer: An umbrella meta-analysis |
| title_full | Statin use and risk of cancer: An umbrella meta-analysis |
| title_fullStr | Statin use and risk of cancer: An umbrella meta-analysis |
| title_full_unstemmed | Statin use and risk of cancer: An umbrella meta-analysis |
| title_short | Statin use and risk of cancer: An umbrella meta-analysis |
| title_sort | statin use and risk of cancer an umbrella meta analysis |
| topic | cancer statin umbrella meta-analysis |
| url | http://www.aort.info/article.asp?issn=2772-8382;year=2023;volume=3;issue=1;spage=14;epage=31;aulast=Kasana |
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