The Role of the Interleukin-1 Family in Complications of Prematurity
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter injury (WMI, brain), retinopathy of prematurity (ROP, eyes), n...
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MDPI AG
2023-02-01
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author | Elys A. Green Steven P. Garrick Briana Peterson Philip J. Berger Robert Galinsky Rod W. Hunt Steven X. Cho Jane E. Bourke Marcel F. Nold Claudia A. Nold-Petry |
author_facet | Elys A. Green Steven P. Garrick Briana Peterson Philip J. Berger Robert Galinsky Rod W. Hunt Steven X. Cho Jane E. Bourke Marcel F. Nold Claudia A. Nold-Petry |
author_sort | Elys A. Green |
collection | DOAJ |
description | Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter injury (WMI, brain), retinopathy of prematurity (ROP, eyes), necrotizing enterocolitis (NEC, gut) and sepsis are among the major causes of long-term morbidity in infants born prematurely. Though the origins are multifactorial, inflammation and in particular the imbalance of pro- and anti-inflammatory mediators is now recognized as a key driver of the pathophysiology underlying these illnesses. Here, we review the involvement of the interleukin (IL)-1 family in perinatal inflammation and its clinical implications, with a focus on the potential of these cytokines as therapeutic targets for the development of safe and effective treatments for early life inflammatory diseases. |
first_indexed | 2024-03-11T09:39:42Z |
format | Article |
id | doaj.art-385138401cc346378560e4dd652fe312 |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-11T09:39:42Z |
publishDate | 2023-02-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-385138401cc346378560e4dd652fe3122023-11-16T17:02:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01243279510.3390/ijms24032795The Role of the Interleukin-1 Family in Complications of PrematurityElys A. Green0Steven P. Garrick1Briana Peterson2Philip J. Berger3Robert Galinsky4Rod W. Hunt5Steven X. Cho6Jane E. Bourke7Marcel F. Nold8Claudia A. Nold-Petry9Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaDepartment of Pharmacology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3168, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC 3168, AustraliaPreterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter injury (WMI, brain), retinopathy of prematurity (ROP, eyes), necrotizing enterocolitis (NEC, gut) and sepsis are among the major causes of long-term morbidity in infants born prematurely. Though the origins are multifactorial, inflammation and in particular the imbalance of pro- and anti-inflammatory mediators is now recognized as a key driver of the pathophysiology underlying these illnesses. Here, we review the involvement of the interleukin (IL)-1 family in perinatal inflammation and its clinical implications, with a focus on the potential of these cytokines as therapeutic targets for the development of safe and effective treatments for early life inflammatory diseases.https://www.mdpi.com/1422-0067/24/3/2795prematurityinflammationbronchopulmonary dysplasiapulmonary hypertensionwhite matter injurycerebral palsy |
spellingShingle | Elys A. Green Steven P. Garrick Briana Peterson Philip J. Berger Robert Galinsky Rod W. Hunt Steven X. Cho Jane E. Bourke Marcel F. Nold Claudia A. Nold-Petry The Role of the Interleukin-1 Family in Complications of Prematurity International Journal of Molecular Sciences prematurity inflammation bronchopulmonary dysplasia pulmonary hypertension white matter injury cerebral palsy |
title | The Role of the Interleukin-1 Family in Complications of Prematurity |
title_full | The Role of the Interleukin-1 Family in Complications of Prematurity |
title_fullStr | The Role of the Interleukin-1 Family in Complications of Prematurity |
title_full_unstemmed | The Role of the Interleukin-1 Family in Complications of Prematurity |
title_short | The Role of the Interleukin-1 Family in Complications of Prematurity |
title_sort | role of the interleukin 1 family in complications of prematurity |
topic | prematurity inflammation bronchopulmonary dysplasia pulmonary hypertension white matter injury cerebral palsy |
url | https://www.mdpi.com/1422-0067/24/3/2795 |
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