Formulation of Budesonide-Loaded Polymeric Nanoparticles into Hydrogels for Local Therapy of Atopic Dermatitis
Budesonide is a mineral corticoid applied in the local therapy of pediatric atopic dermatitis. Unfortunately, its dermal administration is hindered by the concomitant adverse effects and its physicochemical properties. The characteristic pH change in the atopic lesions can be utilized for the prepar...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Online Access: | https://www.mdpi.com/2310-2861/10/1/79 |
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| author | Marta Slavkova Christophor Lazov Ivanka Spassova Daniela Kovacheva Ivanka Pencheva-El Tibi Denitsa Stefanova Virginia Tzankova Petar D. Petrov Krassimira Yoncheva |
| author_facet | Marta Slavkova Christophor Lazov Ivanka Spassova Daniela Kovacheva Ivanka Pencheva-El Tibi Denitsa Stefanova Virginia Tzankova Petar D. Petrov Krassimira Yoncheva |
| author_sort | Marta Slavkova |
| collection | DOAJ |
| description | Budesonide is a mineral corticoid applied in the local therapy of pediatric atopic dermatitis. Unfortunately, its dermal administration is hindered by the concomitant adverse effects and its physicochemical properties. The characteristic pH change in the atopic lesions can be utilized for the preparation of a pH-sensitive nanocarrier. In this view, the formulation of Eudragit L 100 nanoparticles as a budesonide delivery platform could provide more efficient release to the desired site, improve its penetration, and subsequently lower the undesired effects. In this study, budesonide-loaded Eudragit L100 nanoparticles were prepared via the nanoprecipitation method (mean diameter 57 nm, −31.2 mV, and approx. 90% encapsulation efficiency). Their safety was proven by cytotoxicity assays on the HaCaT keratinocyte cell line. Further, the drug-loaded nanoparticles were incorporated into two types of hydrogels based on methylcellulose or Pluronic F127. The formulated hydrogels were characterized with respect to their pH, occlusion, rheology, penetration, spreadability, and drug release. In conclusion, the developed hydrogels containing budesonide-loaded nanoparticles showed promising potential for the pediatric treatment of atopic dermatitis. |
| first_indexed | 2024-03-08T10:54:05Z |
| format | Article |
| id | doaj.art-385186e0651d4a3d81290ed3ca5e8acb |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-08T10:54:05Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-385186e0651d4a3d81290ed3ca5e8acb2024-01-26T16:40:57ZengMDPI AGGels2310-28612024-01-011017910.3390/gels10010079Formulation of Budesonide-Loaded Polymeric Nanoparticles into Hydrogels for Local Therapy of Atopic DermatitisMarta Slavkova0Christophor Lazov1Ivanka Spassova2Daniela Kovacheva3Ivanka Pencheva-El Tibi4Denitsa Stefanova5Virginia Tzankova6Petar D. Petrov7Krassimira Yoncheva8Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, BulgariaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, BulgariaInstitute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaInstitute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, BulgariaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, BulgariaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, BulgariaInstitute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Str. 103A, 1113 Sofia, BulgariaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, BulgariaBudesonide is a mineral corticoid applied in the local therapy of pediatric atopic dermatitis. Unfortunately, its dermal administration is hindered by the concomitant adverse effects and its physicochemical properties. The characteristic pH change in the atopic lesions can be utilized for the preparation of a pH-sensitive nanocarrier. In this view, the formulation of Eudragit L 100 nanoparticles as a budesonide delivery platform could provide more efficient release to the desired site, improve its penetration, and subsequently lower the undesired effects. In this study, budesonide-loaded Eudragit L100 nanoparticles were prepared via the nanoprecipitation method (mean diameter 57 nm, −31.2 mV, and approx. 90% encapsulation efficiency). Their safety was proven by cytotoxicity assays on the HaCaT keratinocyte cell line. Further, the drug-loaded nanoparticles were incorporated into two types of hydrogels based on methylcellulose or Pluronic F127. The formulated hydrogels were characterized with respect to their pH, occlusion, rheology, penetration, spreadability, and drug release. In conclusion, the developed hydrogels containing budesonide-loaded nanoparticles showed promising potential for the pediatric treatment of atopic dermatitis.https://www.mdpi.com/2310-2861/10/1/79budesonidenanoparticlesEudragit L100hydrogelsatopic dermatitis |
| spellingShingle | Marta Slavkova Christophor Lazov Ivanka Spassova Daniela Kovacheva Ivanka Pencheva-El Tibi Denitsa Stefanova Virginia Tzankova Petar D. Petrov Krassimira Yoncheva Formulation of Budesonide-Loaded Polymeric Nanoparticles into Hydrogels for Local Therapy of Atopic Dermatitis Gels budesonide nanoparticles Eudragit L100 hydrogels atopic dermatitis |
| title | Formulation of Budesonide-Loaded Polymeric Nanoparticles into Hydrogels for Local Therapy of Atopic Dermatitis |
| title_full | Formulation of Budesonide-Loaded Polymeric Nanoparticles into Hydrogels for Local Therapy of Atopic Dermatitis |
| title_fullStr | Formulation of Budesonide-Loaded Polymeric Nanoparticles into Hydrogels for Local Therapy of Atopic Dermatitis |
| title_full_unstemmed | Formulation of Budesonide-Loaded Polymeric Nanoparticles into Hydrogels for Local Therapy of Atopic Dermatitis |
| title_short | Formulation of Budesonide-Loaded Polymeric Nanoparticles into Hydrogels for Local Therapy of Atopic Dermatitis |
| title_sort | formulation of budesonide loaded polymeric nanoparticles into hydrogels for local therapy of atopic dermatitis |
| topic | budesonide nanoparticles Eudragit L100 hydrogels atopic dermatitis |
| url | https://www.mdpi.com/2310-2861/10/1/79 |
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