Staging and neuroprogression in bipolar disorder: a systematic review of the literature
INTRODUCTION: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term "neuroprogression" has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders....
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2013-03-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100013 |
| _version_ | 1818019996003991552 |
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| author | Clarissa Severino Gama Maurício Kunz Pedro V.S. Magalhães Flavio Kapczinski |
| author_facet | Clarissa Severino Gama Maurício Kunz Pedro V.S. Magalhães Flavio Kapczinski |
| author_sort | Clarissa Severino Gama |
| collection | DOAJ |
| description | INTRODUCTION: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term "neuroprogression" has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. METHOD: A search in the PubMed database was performed with the following terms: "staging", "neuroprogression", "serum", "plasma", "blood", "neuroimaging", "PET scan", "fMRI", "neurotrophins", "inflammatory markers" and "oxidative stress markers", which were individually crossed with "cognition", "functionality", "response to treatments" and "bipolar disorder". The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. RESULTS: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. CONCLUSION: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies. |
| first_indexed | 2024-04-14T07:59:18Z |
| format | Article |
| id | doaj.art-38519ffe5c5f4998ad738708efd0c20a |
| institution | Directory Open Access Journal |
| issn | 1516-4446 1809-452X |
| language | English |
| last_indexed | 2024-04-14T07:59:18Z |
| publishDate | 2013-03-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-38519ffe5c5f4998ad738708efd0c20a2022-12-22T02:04:56ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1516-44461809-452X2013-03-013517074Staging and neuroprogression in bipolar disorder: a systematic review of the literatureClarissa Severino GamaMaurício KunzPedro V.S. MagalhãesFlavio KapczinskiINTRODUCTION: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term "neuroprogression" has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. METHOD: A search in the PubMed database was performed with the following terms: "staging", "neuroprogression", "serum", "plasma", "blood", "neuroimaging", "PET scan", "fMRI", "neurotrophins", "inflammatory markers" and "oxidative stress markers", which were individually crossed with "cognition", "functionality", "response to treatments" and "bipolar disorder". The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. RESULTS: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. CONCLUSION: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100013Bipolar DisorderClinical ResponseNeuroimagingNeuroprogressionSerum BiomarkersStaging |
| spellingShingle | Clarissa Severino Gama Maurício Kunz Pedro V.S. Magalhães Flavio Kapczinski Staging and neuroprogression in bipolar disorder: a systematic review of the literature Brazilian Journal of Psychiatry Bipolar Disorder Clinical Response Neuroimaging Neuroprogression Serum Biomarkers Staging |
| title | Staging and neuroprogression in bipolar disorder: a systematic review of the literature |
| title_full | Staging and neuroprogression in bipolar disorder: a systematic review of the literature |
| title_fullStr | Staging and neuroprogression in bipolar disorder: a systematic review of the literature |
| title_full_unstemmed | Staging and neuroprogression in bipolar disorder: a systematic review of the literature |
| title_short | Staging and neuroprogression in bipolar disorder: a systematic review of the literature |
| title_sort | staging and neuroprogression in bipolar disorder a systematic review of the literature |
| topic | Bipolar Disorder Clinical Response Neuroimaging Neuroprogression Serum Biomarkers Staging |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000100013 |
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