Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization.
OBJECTIVE:This study investigates associations between cortical thickness and pain duration, and central sensitization as markers of pain progression in painful knee osteoarthritis. METHODS:Whole brain cortical thickness and pressure pain thresholds were assessed in 70 participants; 40 patients with...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5033394?pdf=render |
| _version_ | 1818195988203962368 |
|---|---|
| author | Hamza M Alshuft Laura A Condon Robert A Dineen Dorothee P Auer |
| author_facet | Hamza M Alshuft Laura A Condon Robert A Dineen Dorothee P Auer |
| author_sort | Hamza M Alshuft |
| collection | DOAJ |
| description | OBJECTIVE:This study investigates associations between cortical thickness and pain duration, and central sensitization as markers of pain progression in painful knee osteoarthritis. METHODS:Whole brain cortical thickness and pressure pain thresholds were assessed in 70 participants; 40 patients with chronic painful knee osteoarthritis (age = 66.1± 8.5 years, 21 females, mean duration of pain = 8.5 years), and 30 healthy controls (age = 62.7± 7.4, 17 females). RESULTS:Cortical thickness negatively correlated with pain duration mainly in fronto-temporal areas outside of classical pain processing areas (p<0.05, age-controlled, FDR corrected). Pain sensitivity was unrelated to cortical thickness. Patients showed lower cortical thickness in the right anterior insula (p<0.001, uncorrected) with no changes surviving multiple test correction. CONCLUSION:With increasing number of years of suffering from chronic arthritis pain we found increasing cortical thinning in extended cerebral cortical regions beyond recognised pain-processing areas. While the mechanisms of cortical thinning remain to be elucidated, we show that pain progression indexed by central sensitization does not play a major role. |
| first_indexed | 2024-12-12T01:26:56Z |
| format | Article |
| id | doaj.art-38532dd0c53e402cb51bf047d6e0d4e2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T01:26:56Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-38532dd0c53e402cb51bf047d6e0d4e22022-12-22T00:43:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01119e016168710.1371/journal.pone.0161687Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization.Hamza M AlshuftLaura A CondonRobert A DineenDorothee P AuerOBJECTIVE:This study investigates associations between cortical thickness and pain duration, and central sensitization as markers of pain progression in painful knee osteoarthritis. METHODS:Whole brain cortical thickness and pressure pain thresholds were assessed in 70 participants; 40 patients with chronic painful knee osteoarthritis (age = 66.1± 8.5 years, 21 females, mean duration of pain = 8.5 years), and 30 healthy controls (age = 62.7± 7.4, 17 females). RESULTS:Cortical thickness negatively correlated with pain duration mainly in fronto-temporal areas outside of classical pain processing areas (p<0.05, age-controlled, FDR corrected). Pain sensitivity was unrelated to cortical thickness. Patients showed lower cortical thickness in the right anterior insula (p<0.001, uncorrected) with no changes surviving multiple test correction. CONCLUSION:With increasing number of years of suffering from chronic arthritis pain we found increasing cortical thinning in extended cerebral cortical regions beyond recognised pain-processing areas. While the mechanisms of cortical thinning remain to be elucidated, we show that pain progression indexed by central sensitization does not play a major role.http://europepmc.org/articles/PMC5033394?pdf=render |
| spellingShingle | Hamza M Alshuft Laura A Condon Robert A Dineen Dorothee P Auer Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. PLoS ONE |
| title | Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. |
| title_full | Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. |
| title_fullStr | Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. |
| title_full_unstemmed | Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. |
| title_short | Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. |
| title_sort | cerebral cortical thickness in chronic pain due to knee osteoarthritis the effect of pain duration and pain sensitization |
| url | http://europepmc.org/articles/PMC5033394?pdf=render |
| work_keys_str_mv | AT hamzamalshuft cerebralcorticalthicknessinchronicpainduetokneeosteoarthritistheeffectofpaindurationandpainsensitization AT lauraacondon cerebralcorticalthicknessinchronicpainduetokneeosteoarthritistheeffectofpaindurationandpainsensitization AT robertadineen cerebralcorticalthicknessinchronicpainduetokneeosteoarthritistheeffectofpaindurationandpainsensitization AT dorotheepauer cerebralcorticalthicknessinchronicpainduetokneeosteoarthritistheeffectofpaindurationandpainsensitization |