Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials
Aim. To evaluate the structure and predictors of vascular complications in Takayasu’s arteritis (TA) patients.Material and methods. Overall 183 TA patients have been treated at the Sverdlovsk Regional Clinical Hospital № 1 during the period from 1979 to 2018. Besides, the results of 22 autopsies per...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2019-11-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/823 |
| _version_ | 1797882381597671424 |
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| author | I. E. Borodina A. A. Popov L. A. Shardina G. G. Salavatova A. V. Spirin |
| author_facet | I. E. Borodina A. A. Popov L. A. Shardina G. G. Salavatova A. V. Spirin |
| author_sort | I. E. Borodina |
| collection | DOAJ |
| description | Aim. To evaluate the structure and predictors of vascular complications in Takayasu’s arteritis (TA) patients.Material and methods. Overall 183 TA patients have been treated at the Sverdlovsk Regional Clinical Hospital № 1 during the period from 1979 to 2018. Besides, the results of 22 autopsies performed at the Sverdlovsk State Laboratory of Clinical Pathology at the same period of time.Results. Retrospective analysis revealed that 72 of 183 TA patients had vascular complications. Predictors of vascular complications were: male gender (p=0,002), smoking (p=0,002), surgical intervention before the event (p=0,002), arterial hypertension at the disease onset (p=0,011), signs of coronaritis at the disease onset (p<0,001), headache at the disease onset (p=0,028). Autopsy data revealed 17 cases (77%) of arterial and veins thrombosis. Vascular events were the main cause of death in 82% of lethal cases. According to autopsy data, 21 patients (96%) had atherosclerotic lesions of arterial wall (spots, stripes, plaques) combined with TA specific lesions.Conclusion. TA patients are a high-risk group of severe and potentially lethal cardiovascular events and require thorough attention to prophylactic measures. |
| first_indexed | 2024-04-10T03:34:53Z |
| format | Article |
| id | doaj.art-3854f0f2988849d5be7581182903afc5 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:34:53Z |
| publishDate | 2019-11-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-3854f0f2988849d5be7581182903afc52023-03-13T07:23:28Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252019-11-01185909710.15829/1728-8800-2019-5-90-971973Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materialsI. E. Borodina0A. A. Popov1L. A. Shardina2G. G. Salavatova3A. V. Spirin4ГВУЗ СО Областная клиническая больница № 1; ФГБОУ ВО “Уральский государственный медицинский университет” Минздрава РоссииФГБОУ ВО “Уральский государственный медицинский университет” Минздрава РоссииФГБОУ ВО “Уральский государственный медицинский университет” Минздрава РоссииГВУЗ СО Областная клиническая больница № 1ФГБОУ ВО “Уральский государственный медицинский университет” Минздрава России; МБУ Центральная городская клиническая больница № 1 Октябрьского районаAim. To evaluate the structure and predictors of vascular complications in Takayasu’s arteritis (TA) patients.Material and methods. Overall 183 TA patients have been treated at the Sverdlovsk Regional Clinical Hospital № 1 during the period from 1979 to 2018. Besides, the results of 22 autopsies performed at the Sverdlovsk State Laboratory of Clinical Pathology at the same period of time.Results. Retrospective analysis revealed that 72 of 183 TA patients had vascular complications. Predictors of vascular complications were: male gender (p=0,002), smoking (p=0,002), surgical intervention before the event (p=0,002), arterial hypertension at the disease onset (p=0,011), signs of coronaritis at the disease onset (p<0,001), headache at the disease onset (p=0,028). Autopsy data revealed 17 cases (77%) of arterial and veins thrombosis. Vascular events were the main cause of death in 82% of lethal cases. According to autopsy data, 21 patients (96%) had atherosclerotic lesions of arterial wall (spots, stripes, plaques) combined with TA specific lesions.Conclusion. TA patients are a high-risk group of severe and potentially lethal cardiovascular events and require thorough attention to prophylactic measures.https://cardiovascular.elpub.ru/jour/article/view/823артериит такаясусосудистые осложнениятромбозпредикторыоценка риска |
| spellingShingle | I. E. Borodina A. A. Popov L. A. Shardina G. G. Salavatova A. V. Spirin Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials Кардиоваскулярная терапия и профилактика артериит такаясу сосудистые осложнения тромбоз предикторы оценка риска |
| title | Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials |
| title_full | Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials |
| title_fullStr | Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials |
| title_full_unstemmed | Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials |
| title_short | Predictors of cardiovascular complications in patients with Takayasu’s arteritis: results of a retrospective study and analysis of autopsy materials |
| title_sort | predictors of cardiovascular complications in patients with takayasu s arteritis results of a retrospective study and analysis of autopsy materials |
| topic | артериит такаясу сосудистые осложнения тромбоз предикторы оценка риска |
| url | https://cardiovascular.elpub.ru/jour/article/view/823 |
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