ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways

ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways

Abstract Background The repair of cranio-maxillofacial bone defects remains a formidable clinical challenge. The Ets variant 2 (ETV2) transcription factor, which belongs to the E26 transformation-specific (ETS) family, has been reported to play a key role in neovascularization. However, the role of...

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Bibliographic Details
Main Authors: Jing Li, Haoran Du, Xin Ji, Yihan Chen, Yishuai Li, Boon Chin Heng, Jianguang Xu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Stem Cell Research & Therapy
Subjects:
ETV2
Osteogenic differentiation
Human dental pulp stem cells
Bone formation
RNA-sequencing
Online Access:https://doi.org/10.1186/s13287-022-03052-2

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