Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View
Neurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex aetiologies. Understanding the common biochemical molecular pathologies among NDDs gives an opportunity to decipher the overlapping an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/18/2318 |
| _version_ | 1797580795999682560 |
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| author | Nitesh Sanghai Geoffrey K. Tranmer |
| author_facet | Nitesh Sanghai Geoffrey K. Tranmer |
| author_sort | Nitesh Sanghai |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex aetiologies. Understanding the common biochemical molecular pathologies among NDDs gives an opportunity to decipher the overlapping and numerous cross-talk mechanisms of neurodegeneration. Numerous interrelated pathways lead to the progression of neurodegeneration. We present evidence from the past pieces of literature for the most usual global convergent hallmarks like ageing, oxidative stress, excitotoxicity-induced calcium butterfly effect, defective proteostasis including chaperones, autophagy, mitophagy, and proteosome networks, and neuroinflammation. Herein, we applied a holistic approach to identify and represent the shared mechanism across NDDs. Further, we believe that this approach could be helpful in identifying key modulators across NDDs, with a particular focus on AD, PD, and ALS. Moreover, these concepts could be applied to the development and diagnosis of novel strategies for diverse NDDs. |
| first_indexed | 2024-03-10T22:56:05Z |
| format | Article |
| id | doaj.art-3855c14ce1134ae4a0097a9bd01f52aa |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T22:56:05Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3855c14ce1134ae4a0097a9bd01f52aa2023-11-19T10:00:20ZengMDPI AGCells2073-44092023-09-011218231810.3390/cells12182318Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated ViewNitesh Sanghai0Geoffrey K. Tranmer1College of Pharmacy, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T5, CanadaCollege of Pharmacy, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB R3E 0T5, CanadaNeurodegenerative diseases (NDDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex aetiologies. Understanding the common biochemical molecular pathologies among NDDs gives an opportunity to decipher the overlapping and numerous cross-talk mechanisms of neurodegeneration. Numerous interrelated pathways lead to the progression of neurodegeneration. We present evidence from the past pieces of literature for the most usual global convergent hallmarks like ageing, oxidative stress, excitotoxicity-induced calcium butterfly effect, defective proteostasis including chaperones, autophagy, mitophagy, and proteosome networks, and neuroinflammation. Herein, we applied a holistic approach to identify and represent the shared mechanism across NDDs. Further, we believe that this approach could be helpful in identifying key modulators across NDDs, with a particular focus on AD, PD, and ALS. Moreover, these concepts could be applied to the development and diagnosis of novel strategies for diverse NDDs.https://www.mdpi.com/2073-4409/12/18/2318neurodegenerative diseasesAlzheimer’s diseaseParkinson’s diseaseamyotrophic lateral sclerosisageingoxidative stress |
| spellingShingle | Nitesh Sanghai Geoffrey K. Tranmer Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View Cells neurodegenerative diseases Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis ageing oxidative stress |
| title | Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View |
| title_full | Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View |
| title_fullStr | Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View |
| title_full_unstemmed | Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View |
| title_short | Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View |
| title_sort | biochemical and molecular pathways in neurodegenerative diseases an integrated view |
| topic | neurodegenerative diseases Alzheimer’s disease Parkinson’s disease amyotrophic lateral sclerosis ageing oxidative stress |
| url | https://www.mdpi.com/2073-4409/12/18/2318 |
| work_keys_str_mv | AT niteshsanghai biochemicalandmolecularpathwaysinneurodegenerativediseasesanintegratedview AT geoffreyktranmer biochemicalandmolecularpathwaysinneurodegenerativediseasesanintegratedview |