γδ T cells and their clinical application in colon cancer
In recent years, research has focused on colorectal cancer to implement modern treatment approaches to improve patient survival. In this new era, γδ T cells constitute a new and promising candidate to treat many types of cancer because of their potent killing activity and their ability to recognize...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1098847/full |
| _version_ | 1828051246613790720 |
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| author | Anna Maria Corsale Anna Maria Corsale Anna Maria Corsale Marta Di Simone Marta Di Simone Marta Di Simone Elena Lo Presti Francesco Dieli Francesco Dieli Serena Meraviglia Serena Meraviglia |
| author_facet | Anna Maria Corsale Anna Maria Corsale Anna Maria Corsale Marta Di Simone Marta Di Simone Marta Di Simone Elena Lo Presti Francesco Dieli Francesco Dieli Serena Meraviglia Serena Meraviglia |
| author_sort | Anna Maria Corsale |
| collection | DOAJ |
| description | In recent years, research has focused on colorectal cancer to implement modern treatment approaches to improve patient survival. In this new era, γδ T cells constitute a new and promising candidate to treat many types of cancer because of their potent killing activity and their ability to recognize tumor antigens independently of HLA molecules. Here, we focus on the roles that γδ T cells play in antitumor immunity, especially in colorectal cancer. Furthermore, we provide an overview of small-scale clinical trials in patients with colorectal cancer employing either in vivo activation or adoptive transfer of ex vivo expanded γδ T cells and suggest possible combinatorial approaches to treat colon cancer. |
| first_indexed | 2024-04-10T19:35:20Z |
| format | Article |
| id | doaj.art-385674b903304a80b0b52040180b861c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T19:35:20Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-385674b903304a80b0b52040180b861c2023-01-30T08:04:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.10988471098847γδ T cells and their clinical application in colon cancerAnna Maria Corsale0Anna Maria Corsale1Anna Maria Corsale2Marta Di Simone3Marta Di Simone4Marta Di Simone5Elena Lo Presti6Francesco Dieli7Francesco Dieli8Serena Meraviglia9Serena Meraviglia10Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnosis (Bi.N.D.) University of Palermo, Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnosis (Bi.N.D.) University of Palermo, Palermo, ItalyInstitute for Biomedical Research and Innovation (IRIB), National Research Council (CNR)I, Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnosis (Bi.N.D.) University of Palermo, Palermo, ItalyCentral Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnosis (Bi.N.D.) University of Palermo, Palermo, ItalyIn recent years, research has focused on colorectal cancer to implement modern treatment approaches to improve patient survival. In this new era, γδ T cells constitute a new and promising candidate to treat many types of cancer because of their potent killing activity and their ability to recognize tumor antigens independently of HLA molecules. Here, we focus on the roles that γδ T cells play in antitumor immunity, especially in colorectal cancer. Furthermore, we provide an overview of small-scale clinical trials in patients with colorectal cancer employing either in vivo activation or adoptive transfer of ex vivo expanded γδ T cells and suggest possible combinatorial approaches to treat colon cancer.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1098847/fullgamma delta T cellsimmunotherapycolon rectal cancerMHC- unrestricted activationtumor |
| spellingShingle | Anna Maria Corsale Anna Maria Corsale Anna Maria Corsale Marta Di Simone Marta Di Simone Marta Di Simone Elena Lo Presti Francesco Dieli Francesco Dieli Serena Meraviglia Serena Meraviglia γδ T cells and their clinical application in colon cancer Frontiers in Immunology gamma delta T cells immunotherapy colon rectal cancer MHC- unrestricted activation tumor |
| title | γδ T cells and their clinical application in colon cancer |
| title_full | γδ T cells and their clinical application in colon cancer |
| title_fullStr | γδ T cells and their clinical application in colon cancer |
| title_full_unstemmed | γδ T cells and their clinical application in colon cancer |
| title_short | γδ T cells and their clinical application in colon cancer |
| title_sort | γδ t cells and their clinical application in colon cancer |
| topic | gamma delta T cells immunotherapy colon rectal cancer MHC- unrestricted activation tumor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1098847/full |
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