The Role of Kiss1 Neurons As Integrators of Endocrine, Metabolic, and Environmental Factors in the Hypothalamic–Pituitary–Gonadal Axis

The Role of Kiss1 Neurons As Integrators of Endocrine, Metabolic, and Environmental Factors in the Hypothalamic–Pituitary–Gonadal Axis

Kisspeptin–GPR54 signaling in the hypothalamus is required for reproduction and fertility in mammals. Kiss1 neurons are key regulators of gonadotropin-releasing hormone (GnRH) release and modulation of the hypothalamic–pituitary–gonadal (HPG) axis. Arcuate Kiss1 neurons project to GnRH nerve termina...

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Bibliographic Details
Main Authors:	Shel-Hwa Yeo, William H. Colledge
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-04-01
Series:	Frontiers in Endocrinology
Subjects:	Kiss1 hypothalamus arcuate nucleus gonadotropin-releasing hormone neural afferents luteinizing hormone
Online Access:	http://journal.frontiersin.org/article/10.3389/fendo.2018.00188/full

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