Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex
A growing body of literature shows there are sex differences in the patterns of brain activity during long-term memory. However, there is a paucity of evidence on sex differences in functional brain connectivity. We previously identified sex differences in the patterns of connections with the hippoc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/3/446 |
| _version_ | 1797613048794447872 |
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| author | Dylan S. Spets Scott D. Slotnick |
| author_facet | Dylan S. Spets Scott D. Slotnick |
| author_sort | Dylan S. Spets |
| collection | DOAJ |
| description | A growing body of literature shows there are sex differences in the patterns of brain activity during long-term memory. However, there is a paucity of evidence on sex differences in functional brain connectivity. We previously identified sex differences in the patterns of connections with the hippocampus, a medial temporal lobe (MTL) subregion, during spatial long-term memory. The perirhinal/entorhinal cortex, another MTL subregion, plays a critical role in item memory. In the current functional magnetic resonance imaging (fMRI) study, we investigated perirhinal/entorhinal functional connectivity and the role of sex during item memory. During the study phase, abstract shapes were presented to the left or right of fixation. During the test phase, abstract shapes were presented at fixation, and the participants classified each item as previously “old” or “new”. An entorhinal region of interest (ROI) was identified by contrasting item memory hits and misses. This ROI was connected to regions generally associated with visual memory, including the right inferior frontal gyrus (IFG) and visual-processing regions (the bilateral V1, bilateral cuneus, and left lingual gyrus). Males produced greater connectivity than females with the right IFG/insula and the right V1/bilateral cuneus. Broadly, these results contribute to a growing body of literature supporting sex differences in the brain. |
| first_indexed | 2024-03-11T06:50:26Z |
| format | Article |
| id | doaj.art-3857aa2971a54640ba11697208206160 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T06:50:26Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-3857aa2971a54640ba116972082061602023-11-17T09:59:56ZengMDPI AGBrain Sciences2076-34252023-03-0113344610.3390/brainsci13030446Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of SexDylan S. Spets0Scott D. Slotnick1Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467, USAA growing body of literature shows there are sex differences in the patterns of brain activity during long-term memory. However, there is a paucity of evidence on sex differences in functional brain connectivity. We previously identified sex differences in the patterns of connections with the hippocampus, a medial temporal lobe (MTL) subregion, during spatial long-term memory. The perirhinal/entorhinal cortex, another MTL subregion, plays a critical role in item memory. In the current functional magnetic resonance imaging (fMRI) study, we investigated perirhinal/entorhinal functional connectivity and the role of sex during item memory. During the study phase, abstract shapes were presented to the left or right of fixation. During the test phase, abstract shapes were presented at fixation, and the participants classified each item as previously “old” or “new”. An entorhinal region of interest (ROI) was identified by contrasting item memory hits and misses. This ROI was connected to regions generally associated with visual memory, including the right inferior frontal gyrus (IFG) and visual-processing regions (the bilateral V1, bilateral cuneus, and left lingual gyrus). Males produced greater connectivity than females with the right IFG/insula and the right V1/bilateral cuneus. Broadly, these results contribute to a growing body of literature supporting sex differences in the brain.https://www.mdpi.com/2076-3425/13/3/446sex differencesgender differencesgPPIentorhinal cortexperirhinal cortex |
| spellingShingle | Dylan S. Spets Scott D. Slotnick Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex Brain Sciences sex differences gender differences gPPI entorhinal cortex perirhinal cortex |
| title | Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex |
| title_full | Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex |
| title_fullStr | Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex |
| title_full_unstemmed | Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex |
| title_short | Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex |
| title_sort | entorhinal cortex functional connectivity during item long term memory and the role of sex |
| topic | sex differences gender differences gPPI entorhinal cortex perirhinal cortex |
| url | https://www.mdpi.com/2076-3425/13/3/446 |
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