A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule Development
Formation and regulation of properly sized epithelial tubes is essential for multicellular life. The excretory canal cell of <i>C. elegans</i> provides a powerful model for investigating the integration of the cytoskeleton, intracellular transport, and organismal physiology to regulate t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | https://www.mdpi.com/2221-3759/8/3/17 |
| _version_ | 1797554401918844928 |
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| author | Matthew Buechner Zhe Yang Hikmat Al-Hashimi |
| author_facet | Matthew Buechner Zhe Yang Hikmat Al-Hashimi |
| author_sort | Matthew Buechner |
| collection | DOAJ |
| description | Formation and regulation of properly sized epithelial tubes is essential for multicellular life. The excretory canal cell of <i>C. elegans</i> provides a powerful model for investigating the integration of the cytoskeleton, intracellular transport, and organismal physiology to regulate the developmental processes of tube extension, lumen formation, and lumen diameter regulation in a narrow single cell. Multiple studies have provided new understanding of actin and intermediate filament cytoskeletal elements, vesicle transport, and the role of vacuolar ATPase in determining tube size. Most of the genes discovered have clear homologues in humans, with implications for understanding these processes in mammalian tissues such as Schwann cells, renal tubules, and brain vasculature. The results of several new genetic screens are described that provide a host of new targets for future studies in this informative structure. |
| first_indexed | 2024-03-10T16:31:42Z |
| format | Article |
| id | doaj.art-3858cc4af29b47018ce73cea8739e49a |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-03-10T16:31:42Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-3858cc4af29b47018ce73cea8739e49a2023-11-20T12:49:08ZengMDPI AGJournal of Developmental Biology2221-37592020-09-01831710.3390/jdb8030017A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule DevelopmentMatthew Buechner0Zhe Yang1Hikmat Al-Hashimi2Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USADepartment of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USADeciphera, Pharmaceuticals, Inc., Lawrence, KS 66044, USAFormation and regulation of properly sized epithelial tubes is essential for multicellular life. The excretory canal cell of <i>C. elegans</i> provides a powerful model for investigating the integration of the cytoskeleton, intracellular transport, and organismal physiology to regulate the developmental processes of tube extension, lumen formation, and lumen diameter regulation in a narrow single cell. Multiple studies have provided new understanding of actin and intermediate filament cytoskeletal elements, vesicle transport, and the role of vacuolar ATPase in determining tube size. Most of the genes discovered have clear homologues in humans, with implications for understanding these processes in mammalian tissues such as Schwann cells, renal tubules, and brain vasculature. The results of several new genetic screens are described that provide a host of new targets for future studies in this informative structure.https://www.mdpi.com/2221-3759/8/3/17epithelial tubeapical surfacevesicle transportexocytosisvacuolar ATPaseintermediate filaments |
| spellingShingle | Matthew Buechner Zhe Yang Hikmat Al-Hashimi A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule Development Journal of Developmental Biology epithelial tube apical surface vesicle transport exocytosis vacuolar ATPase intermediate filaments |
| title | A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule Development |
| title_full | A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule Development |
| title_fullStr | A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule Development |
| title_full_unstemmed | A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule Development |
| title_short | A Series of Tubes: The <i>C. elegans</i> Excretory Canal Cell as a Model for Tubule Development |
| title_sort | series of tubes the i c elegans i excretory canal cell as a model for tubule development |
| topic | epithelial tube apical surface vesicle transport exocytosis vacuolar ATPase intermediate filaments |
| url | https://www.mdpi.com/2221-3759/8/3/17 |
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