Evaluation of different metrics as an index for the assessment of arterial stiffness
Elevated intravascular pressure is a contributing factor to increased arterial stiffness, and is a risk factor for cardiovascular morbidity and mortality. Assessment of arterial stiffness is of importance in evaluating cardiovascular risk. Pulse wave velocity (PWV) has been broadly used in the asses...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1384484 |
| _version_ | 1797681365843443712 |
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| author | Camille Leblanc Hilary R Strong Reza Tabrizchi |
| author_facet | Camille Leblanc Hilary R Strong Reza Tabrizchi |
| author_sort | Camille Leblanc |
| collection | DOAJ |
| description | Elevated intravascular pressure is a contributing factor to increased arterial stiffness, and is a risk factor for cardiovascular morbidity and mortality. Assessment of arterial stiffness is of importance in evaluating cardiovascular risk. Pulse wave velocity (PWV) has been broadly used in the assessment of arterial stiffness. We compared three different metrics of arterial stiffness to PWV. Hemodynamic recordings were carried out in anesthetized hypertensive and normotensive rats (n = 25; 13–14 weeks old). Four parameters were calculated (PWV, elastic modulus (Einc), stiffness index (β), and pressure-strain modulus (Ep)) as metrics of arterial stiffness. Hypertensive in comparison to normotensive rats had significantly higher systolic and diastolic blood pressures. Metric for arterial stiffness were significantly (p < 0.002) higher in hypertensive animals: PWV (8.46 ± 2.01 vs. 6.39 ± 1.28 m/s), Ep (0.246 ± 0.019 vs. 0.137 ± 0.010 dyn/cm2 × 10–6), Einc (17.5 ± 1.8 vs. 10.1 ± 0.9 dyn/cm2 × 10–6), and β (2.43 ± 0.11 vs. 1.98 ± 0.08) (mean±SE). Bland-Altman analysis revealed β as the only metric aligned with PWV in hypertensive state. We find in state of reduced arterial compliance associated with high systemic pressure, β but not Einc or Ep is an index of arterial stiffness showing agreement with PWV. |
| first_indexed | 2024-03-11T23:43:51Z |
| format | Article |
| id | doaj.art-3859312711b847ccb5167727aab39711 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:51Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-3859312711b847ccb5167727aab397112023-09-19T15:19:26ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062018-05-0140439039710.1080/10641963.2017.13844841384484Evaluation of different metrics as an index for the assessment of arterial stiffnessCamille Leblanc0Hilary R Strong1Reza Tabrizchi2Memorial University of NewfoundlandMemorial University of NewfoundlandMemorial University of NewfoundlandElevated intravascular pressure is a contributing factor to increased arterial stiffness, and is a risk factor for cardiovascular morbidity and mortality. Assessment of arterial stiffness is of importance in evaluating cardiovascular risk. Pulse wave velocity (PWV) has been broadly used in the assessment of arterial stiffness. We compared three different metrics of arterial stiffness to PWV. Hemodynamic recordings were carried out in anesthetized hypertensive and normotensive rats (n = 25; 13–14 weeks old). Four parameters were calculated (PWV, elastic modulus (Einc), stiffness index (β), and pressure-strain modulus (Ep)) as metrics of arterial stiffness. Hypertensive in comparison to normotensive rats had significantly higher systolic and diastolic blood pressures. Metric for arterial stiffness were significantly (p < 0.002) higher in hypertensive animals: PWV (8.46 ± 2.01 vs. 6.39 ± 1.28 m/s), Ep (0.246 ± 0.019 vs. 0.137 ± 0.010 dyn/cm2 × 10–6), Einc (17.5 ± 1.8 vs. 10.1 ± 0.9 dyn/cm2 × 10–6), and β (2.43 ± 0.11 vs. 1.98 ± 0.08) (mean±SE). Bland-Altman analysis revealed β as the only metric aligned with PWV in hypertensive state. We find in state of reduced arterial compliance associated with high systemic pressure, β but not Einc or Ep is an index of arterial stiffness showing agreement with PWV.http://dx.doi.org/10.1080/10641963.2017.1384484arterial stiffnesselastic modulushigh intravascular pressurepressure strain moduluspulse wave velocitystiffness index |
| spellingShingle | Camille Leblanc Hilary R Strong Reza Tabrizchi Evaluation of different metrics as an index for the assessment of arterial stiffness Clinical and Experimental Hypertension arterial stiffness elastic modulus high intravascular pressure pressure strain modulus pulse wave velocity stiffness index |
| title | Evaluation of different metrics as an index for the assessment of arterial stiffness |
| title_full | Evaluation of different metrics as an index for the assessment of arterial stiffness |
| title_fullStr | Evaluation of different metrics as an index for the assessment of arterial stiffness |
| title_full_unstemmed | Evaluation of different metrics as an index for the assessment of arterial stiffness |
| title_short | Evaluation of different metrics as an index for the assessment of arterial stiffness |
| title_sort | evaluation of different metrics as an index for the assessment of arterial stiffness |
| topic | arterial stiffness elastic modulus high intravascular pressure pressure strain modulus pulse wave velocity stiffness index |
| url | http://dx.doi.org/10.1080/10641963.2017.1384484 |
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