The translation factors of Drosophila melanogaster
Synthesis of polypeptides from mRNA (translation) is a fundamental cellular process that is coordinated and catalyzed by a set of canonical ‘translation factors’. Surprisingly, the translation factors of Drosophila melanogaster have not yet been systematically identified, leading to inconsistencies...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Fly |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19336934.2016.1220464 |
| _version_ | 1797678346210902016 |
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| author | Steven J. Marygold Helen Attrill Paul Lasko |
| author_facet | Steven J. Marygold Helen Attrill Paul Lasko |
| author_sort | Steven J. Marygold |
| collection | DOAJ |
| description | Synthesis of polypeptides from mRNA (translation) is a fundamental cellular process that is coordinated and catalyzed by a set of canonical ‘translation factors’. Surprisingly, the translation factors of Drosophila melanogaster have not yet been systematically identified, leading to inconsistencies in their nomenclature and shortcomings in functional (Gene Ontology, GO) annotations. Here, we describe the complete set of translation factors in D. melanogaster, applying nomenclature already in widespread use in other species, and revising their functional annotation. The collection comprises 43 initiation factors, 12 elongation factors, 3 release factors and 6 recycling factors, totaling 64 of which 55 are cytoplasmic and 9 are mitochondrial. We also provide an overview of notable findings and particular insights derived from Drosophila about these factors. This catalog, together with the incorporation of the improved nomenclature and GO annotation into FlyBase, will greatly facilitate access to information about the functional roles of these important proteins. |
| first_indexed | 2024-03-11T22:58:23Z |
| format | Article |
| id | doaj.art-385c1b6a366945f4913f62c741005a6e |
| institution | Directory Open Access Journal |
| issn | 1933-6934 1933-6942 |
| language | English |
| last_indexed | 2024-03-11T22:58:23Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Fly |
| spelling | doaj.art-385c1b6a366945f4913f62c741005a6e2023-09-21T15:09:08ZengTaylor & Francis GroupFly1933-69341933-69422017-01-01111657410.1080/19336934.2016.12204641220464The translation factors of Drosophila melanogasterSteven J. Marygold0Helen Attrill1Paul Lasko2Development and Neuroscience, University of CambridgeDevelopment and Neuroscience, University of CambridgeMcGill UniversitySynthesis of polypeptides from mRNA (translation) is a fundamental cellular process that is coordinated and catalyzed by a set of canonical ‘translation factors’. Surprisingly, the translation factors of Drosophila melanogaster have not yet been systematically identified, leading to inconsistencies in their nomenclature and shortcomings in functional (Gene Ontology, GO) annotations. Here, we describe the complete set of translation factors in D. melanogaster, applying nomenclature already in widespread use in other species, and revising their functional annotation. The collection comprises 43 initiation factors, 12 elongation factors, 3 release factors and 6 recycling factors, totaling 64 of which 55 are cytoplasmic and 9 are mitochondrial. We also provide an overview of notable findings and particular insights derived from Drosophila about these factors. This catalog, together with the incorporation of the improved nomenclature and GO annotation into FlyBase, will greatly facilitate access to information about the functional roles of these important proteins.http://dx.doi.org/10.1080/19336934.2016.1220464drosophila melanogastertranslation initiation factortranslation elongation factortranslation termination factortranslation release factortranslation recycling factor |
| spellingShingle | Steven J. Marygold Helen Attrill Paul Lasko The translation factors of Drosophila melanogaster Fly drosophila melanogaster translation initiation factor translation elongation factor translation termination factor translation release factor translation recycling factor |
| title | The translation factors of Drosophila melanogaster |
| title_full | The translation factors of Drosophila melanogaster |
| title_fullStr | The translation factors of Drosophila melanogaster |
| title_full_unstemmed | The translation factors of Drosophila melanogaster |
| title_short | The translation factors of Drosophila melanogaster |
| title_sort | translation factors of drosophila melanogaster |
| topic | drosophila melanogaster translation initiation factor translation elongation factor translation termination factor translation release factor translation recycling factor |
| url | http://dx.doi.org/10.1080/19336934.2016.1220464 |
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