Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events
Abstract To understand the information encoded in a connection between the neurons, postsynaptic current (PSC) has been widely measured as a primary index of synaptic strength in the field of neurophysiology. Although several automatic detection methods for PSCs have been proposed to simplify a work...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-09-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-021-00847-x |
| _version_ | 1818736793840779264 |
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| author | Yong Gyu Kim Jae Jin Shin Sang Jeong Kim |
| author_facet | Yong Gyu Kim Jae Jin Shin Sang Jeong Kim |
| author_sort | Yong Gyu Kim |
| collection | DOAJ |
| description | Abstract To understand the information encoded in a connection between the neurons, postsynaptic current (PSC) has been widely measured as a primary index of synaptic strength in the field of neurophysiology. Although several automatic detection methods for PSCs have been proposed to simplify a workflow in the analysis, repetitive steps such as quantification and management of PSC data should be still performed with much effort. Here, we present Minhee Analysis Package, an integrated standalone software package that is capable of detecting, sorting, and quantifying PSC data. First, we developed a stepwise exploratory algorithm to detect PSC and validated our detection algorithm using the simulated and experimental data. We also described all the features and examples of the package so that users can use and follow them properly. In conclusion, our software package is expected to improve the convenience and efficiency of neurophysiologists to analyze PSC data by simplifying the workflow from detection to quantification. Minhee Analysis Package is freely available to download from http://www.github.com/parkgilbong/Minhee_Analysis_Pack . |
| first_indexed | 2024-12-18T00:42:48Z |
| format | Article |
| id | doaj.art-385d770e04d04d87a5146fddb89785f5 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-18T00:42:48Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-385d770e04d04d87a5146fddb89785f52022-12-21T21:26:50ZengBMCMolecular Brain1756-66062021-09-0114111710.1186/s13041-021-00847-xMinhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic eventsYong Gyu Kim0Jae Jin Shin1Sang Jeong Kim2Department of Physiology, Seoul National University College of MedicineDepartment of Physiology, Seoul National University College of MedicineDepartment of Physiology, Seoul National University College of MedicineAbstract To understand the information encoded in a connection between the neurons, postsynaptic current (PSC) has been widely measured as a primary index of synaptic strength in the field of neurophysiology. Although several automatic detection methods for PSCs have been proposed to simplify a workflow in the analysis, repetitive steps such as quantification and management of PSC data should be still performed with much effort. Here, we present Minhee Analysis Package, an integrated standalone software package that is capable of detecting, sorting, and quantifying PSC data. First, we developed a stepwise exploratory algorithm to detect PSC and validated our detection algorithm using the simulated and experimental data. We also described all the features and examples of the package so that users can use and follow them properly. In conclusion, our software package is expected to improve the convenience and efficiency of neurophysiologists to analyze PSC data by simplifying the workflow from detection to quantification. Minhee Analysis Package is freely available to download from http://www.github.com/parkgilbong/Minhee_Analysis_Pack .https://doi.org/10.1186/s13041-021-00847-xData analysis softwareElectrophysiologyPostsynaptic currentEvent detectionData management |
| spellingShingle | Yong Gyu Kim Jae Jin Shin Sang Jeong Kim Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events Molecular Brain Data analysis software Electrophysiology Postsynaptic current Event detection Data management |
| title | Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events |
| title_full | Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events |
| title_fullStr | Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events |
| title_full_unstemmed | Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events |
| title_short | Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events |
| title_sort | minhee analysis package an integrated software package for detection and management of spontaneous synaptic events |
| topic | Data analysis software Electrophysiology Postsynaptic current Event detection Data management |
| url | https://doi.org/10.1186/s13041-021-00847-x |
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