Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance

Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance

Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad spectrum of structurally and mechanistically unrelated drugs across membranes, severely impairs the response to chemotherapy and leads to chemotherapy failure. Overexpression of ATP binding cassette (ABC) transpor...

Full description

Bibliographic Details
Main Authors:	Huan Xiao, Yongcheng Zheng, Lingling Ma, Lili Tian, Qiu Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Pharmacology
Subjects:	ABCC1 ABCG2 ABCB1 MDR anti-cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.648407/full

Similar Items

Molecular Regulation of Canalicular ABC Transporters
by: Amel Ben Saad, et al.
Published: (2021-02-01)

Analysis of Multiple Drug Resistance Mechanism in Different Types of Soft Tissue Sarcomas: Assessment of the Expression of ABC-Transporters, MVP, YB-1, and Analysis of Their Correlation with Chemosensitivity of Cancer Cells
by: Natalia I. Moiseeva, et al.
Published: (2022-03-01)

Drug resistance of cancer cells is crucially affected by expression levels of ABC-transporters
by: Petr Mlejnek, et al.
Published: (2017-02-01)

Immunofluorescence-Based Assay for High-Throughput Analysis of Multidrug Resistance Markers in Non-Small Cell Lung Carcinoma Patient-Derived Cells
by: Jelena Dinić, et al.
Published: (2023-12-01)

Systematic Review of Pharmacogenetics of ABC and SLC Transporter Genes in Acute Myeloid Leukemia
by: Juan Eduardo Megías-Vericat, et al.
Published: (2022-04-01)

Strategies to gain novel Alzheimer’s disease diagnostics and therapeutics using modulators of ABCA transporters
by: Jens Pahnke, et al.
Published: (2021-12-01)

Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances
by: Li eLiu, et al.
Published: (2014-12-01)

Esters of the Marine-Derived Triterpene Sipholenol A Reverse P-GP-Mediated Drug Resistance
by: Yongchao Zhang, et al.
Published: (2015-04-01)

Nilotinib Enhances the Efficacy of Conventional Chemotherapeutic Drugs in CD34+CD38− Stem Cells and ABC Transporter Overexpressing Leukemia Cells
by: Fang Wang, et al.
Published: (2014-03-01)

Testing of the Survivin Suppressant YM155 in a Large Panel of Drug-Resistant Neuroblastoma Cell Lines
by: Martin Michaelis, et al.
Published: (2020-03-01)

ATP‐Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds
by: Burak YAZGAN, et al.
Published: (2022-04-01)

ABC Efflux Transporters and the Circuitry of miRNAs: Kinetics of Expression in Cancer Drug Resistance
by: Bruno C. Gomes, et al.
Published: (2020-04-01)

Impact of genetic polymorphisms of drug transporters ABCB1 and ABCG2 and regulators of xenobiotic transport and metabolism PXR and CAR on clinical efficacy of dasatinib in chronic myeloid leukemia
by: Anna Marta Madejczyk, et al.
Published: (2022-09-01)

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters
by: Johannes Matthaei, et al.
Published: (2016-11-01)

Pharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations
by: Li X, et al.
Published: (2021-10-01)

Methyl-Cantharidimide (MCA) Has Anticancer Efficacy in ABCB1- and ABCG2-Overexpressing and Cisplatin Resistant Cancer Cells
by: Yi-Dong Li, et al.
Published: (2020-06-01)

VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters
by: Ning Ji, et al.
Published: (2018-10-01)

Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells
by: Yongchao Zhang, et al.
Published: (2020-11-01)

Extracellular Vesicles as Surrogates for the Regulation of the Drug Transporters ABCC2 (MRP2) and ABCG2 (BCRP)
by: Juan Pablo Rigalli, et al.
Published: (2024-04-01)

Identification of multi-drug resistance gene (MDR1) in equine ileum
by: Cláudio Corrêa Natalini, et al.
Published: (2006-02-01)

Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat
by: Chung-Pu Wu, et al.
Published: (2021-03-01)

Novel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function
by: Zhanwei Zeng, et al.
Published: (2022-08-01)

Adverse Drug Reactions After Administration of Emodepside/Praziquantel (Profender®) in an MDR1-Mutant Australian Shepherd Dog: Case Report
by: Daniela Gaens, et al.
Published: (2019-09-01)

Multi-drug resistance gene (MDR1) and opioid analgesia in horses
by: Cláudio Corrêa Natalini, et al.
Published: (2006-02-01)

Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
by: Anna Palko-Łabuz, et al.
Published: (2021-07-01)

Rutaecarpine Increases Anticancer Drug Sensitivity in Drug-Resistant Cells through MARCH8-Dependent ABCB1 Degradation
by: Tingting Zou, et al.
Published: (2021-09-01)

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
by: Lei Zhang, et al.
Published: (2020-01-01)

Transcriptome analysis of ABCB1, ABCG2 and the BCL2/BAX ratio in refractory and relapsed canine lymphomas under treatment and rescue protocol
by: Sirivisoot Sirintra, et al.
Published: (2018-03-01)

Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor
by: Alessandro Barbieri, et al.
Published: (2021-11-01)

First Sequencing of Caprine Mdr1 (Abcb1) mRNA Due to Suspected Neurological Adverse Drug Reaction in a Thuringian Goat Following Extra-Label Use of Doramectin
by: Daniela Nürnberger, et al.
Published: (2021-06-01)

MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines
by: Eva-Maria Packeiser, et al.
Published: (2023-05-01)

Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites
by: Margarida L. F. Martins, et al.
Published: (2022-03-01)

Furmonertinib, a Third-Generation EGFR Tyrosine Kinase Inhibitor, Overcomes Multidrug Resistance through Inhibiting ABCB1 and ABCG2 in Cancer Cells
by: Chung-Pu Wu, et al.
Published: (2023-09-01)

ABCB1 and ABCG2 Overexpression Mediates Resistance to the Phosphatidylinositol 3-Kinase Inhibitor HS-173 in Cancer Cell Lines
by: Chung-Pu Wu, et al.
Published: (2023-03-01)

Impact of <i>ABCG2</i> and <i>ABCB1</i> Polymorphisms on Imatinib Plasmatic Exposure: An Original Work and Meta-Analysis
by: Chiara Dalle Fratte, et al.
Published: (2023-02-01)

ABCB1 and ABCG2 restricts the efficacy of gedatolisib (PF-05212384), a PI3K inhibitor in colorectal cancer cells
by: Changfu Liu, et al.
Published: (2021-02-01)

Meta-Analysis of ABCG2 and ABCB1 Polymorphisms With Sunitinib-Induced Toxicity and Efficacy in Renal Cell Carcinoma
by: Fengjun Sun, et al.
Published: (2021-03-01)

Identification and Empiric Evaluation of New Inhibitors of the Multidrug Transporter P-Glycoprotein (ABCB1)
by: Yasmeen Cheema, et al.
Published: (2023-03-01)

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure
by: Jing Wang, et al.
Published: (2022-09-01)

Exploring Natural Product Activity and Species Source Candidates for Hunting ABCB1 Transporter Inhibitors: An In Silico Drug Discovery Study
by: Mahmoud A. A. Ibrahim, et al.
Published: (2022-05-01)