The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function
Autophagy is an evolutionary conserved and highly regulated recycling process of cellular wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic organelles, proteins, macromolecules, and pathogens, eliminates unnecessary materials and provides nutrients and energy...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/10/1398 |
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| author | Azadeh Montaseri Claudia Giampietri Michela Rossi Anna Riccioli Andrea Del Fattore Antonio Filippini |
| author_facet | Azadeh Montaseri Claudia Giampietri Michela Rossi Anna Riccioli Andrea Del Fattore Antonio Filippini |
| author_sort | Azadeh Montaseri |
| collection | DOAJ |
| description | Autophagy is an evolutionary conserved and highly regulated recycling process of cellular wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic organelles, proteins, macromolecules, and pathogens, eliminates unnecessary materials and provides nutrients and energy for cell survival and maintenance. The critical role of autophagy and autophagy-related proteins in osteoclast differentiation, bone resorption, and maintenance of bone homeostasis has previously been reported. Increasing evidence reveals that autophagy dysregulation leads to alteration of osteoclast function and enhanced bone loss, which is associated with the onset and progression of osteoporosis. In this review, we briefly consolidate the current state-of-the-art technology regarding the role of autophagy in osteoclast function in both physiologic and pathologic conditions to have a more general view on this issue. |
| first_indexed | 2024-03-10T15:54:46Z |
| format | Article |
| id | doaj.art-38638996c10f4973a8a7b63a490f8bea |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T15:54:46Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-38638996c10f4973a8a7b63a490f8bea2023-11-20T15:43:15ZengMDPI AGBiomolecules2218-273X2020-09-011010139810.3390/biom10101398The Role of Autophagy in Osteoclast Differentiation and Bone Resorption FunctionAzadeh Montaseri0Claudia Giampietri1Michela Rossi2Anna Riccioli3Andrea Del Fattore4Antonio Filippini5Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Unit of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Anatomy, Histology, Forensic Medicine and Orthopaedics, Unit of Human Anatomy, Sapienza University of Rome, 00161 Rome, ItalyBone Physiopathology Research Unit, Genetics and Rare Diseases Research Division, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyDepartment of Anatomy, Histology, Forensic Medicine and Orthopaedics, Unit of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyBone Physiopathology Research Unit, Genetics and Rare Diseases Research Division, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyDepartment of Anatomy, Histology, Forensic Medicine and Orthopaedics, Unit of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, ItalyAutophagy is an evolutionary conserved and highly regulated recycling process of cellular wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic organelles, proteins, macromolecules, and pathogens, eliminates unnecessary materials and provides nutrients and energy for cell survival and maintenance. The critical role of autophagy and autophagy-related proteins in osteoclast differentiation, bone resorption, and maintenance of bone homeostasis has previously been reported. Increasing evidence reveals that autophagy dysregulation leads to alteration of osteoclast function and enhanced bone loss, which is associated with the onset and progression of osteoporosis. In this review, we briefly consolidate the current state-of-the-art technology regarding the role of autophagy in osteoclast function in both physiologic and pathologic conditions to have a more general view on this issue.https://www.mdpi.com/2218-273X/10/10/1398autophagyosteoclastdifferentiation |
| spellingShingle | Azadeh Montaseri Claudia Giampietri Michela Rossi Anna Riccioli Andrea Del Fattore Antonio Filippini The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function Biomolecules autophagy osteoclast differentiation |
| title | The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function |
| title_full | The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function |
| title_fullStr | The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function |
| title_full_unstemmed | The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function |
| title_short | The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function |
| title_sort | role of autophagy in osteoclast differentiation and bone resorption function |
| topic | autophagy osteoclast differentiation |
| url | https://www.mdpi.com/2218-273X/10/10/1398 |
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