Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literature
Abstract Background Kaposi’s sarcoma (KS) is a rare vascular tumor associated with human herpesvirus (HHV)-8 infection. One of the variants of KS is defined iatrogenic and is overall reported in transplanted patient but also, although less frequently, in patients treated with long-standing immunosup...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://link.springer.com/article/10.1186/s12876-020-01221-2 |
| _version_ | 1830439928294539264 |
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| author | Valerio Papa Maria Cristina Giustiniani Loris Riccardo Lopetuso Alfredo Papa |
| author_facet | Valerio Papa Maria Cristina Giustiniani Loris Riccardo Lopetuso Alfredo Papa |
| author_sort | Valerio Papa |
| collection | DOAJ |
| description | Abstract Background Kaposi’s sarcoma (KS) is a rare vascular tumor associated with human herpesvirus (HHV)-8 infection. One of the variants of KS is defined iatrogenic and is overall reported in transplanted patient but also, although less frequently, in patients treated with long-standing immunosuppressive therapy, such as in inflammatory bowel disease including ulcerative colitis and Crohn’s disease. Case presentation Herein, we report the first case of KS in a human immunodeficiency virus (HIV)-negative 47-year old male with UC after treatment with the α4-β7 integrin inhibitor vedolizumab (VDZ). The patient underwent to colectomy for a medical refractory disease and the histological examination of the surgical specimen showed the typical findings of KS together with the HHV-8 positivity. The patient achieved a good health status, without any sign of disease recurrence. Conclusions In the present case, we can assume that VDZ may have promoted the reactivation of a latent HHV-8 infection endowed with oncogenic potentialities and, in turn, the onset of KS. We also briefly reviewed all the cases of KS in HIV-negative patients with inflammatory bowel disease. |
| first_indexed | 2024-12-21T04:52:40Z |
| format | Article |
| id | doaj.art-38642fb340474accab2ee03e8b1548b7 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-21T04:52:40Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-38642fb340474accab2ee03e8b1548b72022-12-21T19:15:24ZengBMCBMC Gastroenterology1471-230X2020-03-012011510.1186/s12876-020-01221-2Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literatureValerio Papa0Maria Cristina Giustiniani1Loris Riccardo Lopetuso2Alfredo Papa3Department of Surgery, Fondazione Policlinico A. Gemelli IRCCSDepartment of Pathology, Fondazione Policlinico A. Gemelli IRCCSUOC Medicina Interna e Gastroenterologia, Area Gastroenterologia ed Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCSUOC Medicina Interna e Gastroenterologia, Area Gastroenterologia ed Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCSAbstract Background Kaposi’s sarcoma (KS) is a rare vascular tumor associated with human herpesvirus (HHV)-8 infection. One of the variants of KS is defined iatrogenic and is overall reported in transplanted patient but also, although less frequently, in patients treated with long-standing immunosuppressive therapy, such as in inflammatory bowel disease including ulcerative colitis and Crohn’s disease. Case presentation Herein, we report the first case of KS in a human immunodeficiency virus (HIV)-negative 47-year old male with UC after treatment with the α4-β7 integrin inhibitor vedolizumab (VDZ). The patient underwent to colectomy for a medical refractory disease and the histological examination of the surgical specimen showed the typical findings of KS together with the HHV-8 positivity. The patient achieved a good health status, without any sign of disease recurrence. Conclusions In the present case, we can assume that VDZ may have promoted the reactivation of a latent HHV-8 infection endowed with oncogenic potentialities and, in turn, the onset of KS. We also briefly reviewed all the cases of KS in HIV-negative patients with inflammatory bowel disease.http://link.springer.com/article/10.1186/s12876-020-01221-2Ulcerative colitisKaposi’s sarcomaVedolizumabHuman Herpesvirus-8 |
| spellingShingle | Valerio Papa Maria Cristina Giustiniani Loris Riccardo Lopetuso Alfredo Papa Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literature BMC Gastroenterology Ulcerative colitis Kaposi’s sarcoma Vedolizumab Human Herpesvirus-8 |
| title | Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literature |
| title_full | Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literature |
| title_fullStr | Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literature |
| title_full_unstemmed | Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literature |
| title_short | Human herpesvirus 8-associated colonic Kaposi’s sarcoma during vedolizumab treatment in ulcerative colitis: a case report and review of the literature |
| title_sort | human herpesvirus 8 associated colonic kaposi s sarcoma during vedolizumab treatment in ulcerative colitis a case report and review of the literature |
| topic | Ulcerative colitis Kaposi’s sarcoma Vedolizumab Human Herpesvirus-8 |
| url | http://link.springer.com/article/10.1186/s12876-020-01221-2 |
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