Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa
The etiology of anorexia nervosa (AN) is poorly understood. Results from functional brain imaging studies investigating the neural profile of AN using cognitive and emotional task paradigms are difficult to reconcile. Task-related imaging studies often require a high level of compliance and can only...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00346/full |
| _version_ | 1818537761038139392 |
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| author | Ilka eBoehm Daniel eGeisler Joseph A King Franziska eRitschel Maria eSeidel Yacila eDaza Araujo Juliane ePetermann Heidi eLohmeier Jessika eWeiss Martin eWalter Martin eWalter Veit eRoessner Stefan eEhrlich Stefan eEhrlich Stefan eEhrlich |
| author_facet | Ilka eBoehm Daniel eGeisler Joseph A King Franziska eRitschel Maria eSeidel Yacila eDaza Araujo Juliane ePetermann Heidi eLohmeier Jessika eWeiss Martin eWalter Martin eWalter Veit eRoessner Stefan eEhrlich Stefan eEhrlich Stefan eEhrlich |
| author_sort | Ilka eBoehm |
| collection | DOAJ |
| description | The etiology of anorexia nervosa (AN) is poorly understood. Results from functional brain imaging studies investigating the neural profile of AN using cognitive and emotional task paradigms are difficult to reconcile. Task-related imaging studies often require a high level of compliance and can only partially explore the distributed nature and complexity of brain function. In this study, resting state functional connectivity imaging was used to investigate well-characterized brain networks potentially relevant to understand the neural mechanisms underlying the symptomatology and etiology of AN. Resting state functional magnetic resonance imaging data was obtained from 35 unmedicated female acute AN patients and 35 closely matched healthy female participants (HC) and decomposed using spatial group independent component analyses. Using validated templates, we identified components covering the fronto-parietal control network, the default mode network (DMN), the salience network, the visual and the sensory-motor network. Group comparison revealed an increased functional connectivity between the angular gyrus and the other parts of the fronto-parietal network in patients with AN in comparison to HC. Connectivity of the angular gyrus was positively associated with self-reported persistence in HC. In the DMN, AN patients also showed an increased functional connectivity strength in the anterior insula in comparison to HC. Anterior insula connectivity was associated with self-reported problems with interoceptive awareness. This study, with one of the largest sample to date, shows that acute AN is associated with abnormal brain connectivity in two major resting state networks. The finding of an increased functional connectivity in the fronto-parietal network adds novel support for the notion of AN as a disorder of excessive cognitive control, whereas the elevated functional connectivity of the anterior insula with the DMN may reflect the high levels of self- and body-focus |
| first_indexed | 2024-12-11T18:54:55Z |
| format | Article |
| id | doaj.art-386493fb4c294e059a98a607f52007aa |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-11T18:54:55Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-386493fb4c294e059a98a607f52007aa2022-12-22T00:54:10ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-10-01810.3389/fnbeh.2014.00346110128Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosaIlka eBoehm0Daniel eGeisler1Joseph A King2Franziska eRitschel3Maria eSeidel4Yacila eDaza Araujo5Juliane ePetermann6Heidi eLohmeier7Jessika eWeiss8Martin eWalter9Martin eWalter10Veit eRoessner11Stefan eEhrlich12Stefan eEhrlich13Stefan eEhrlich14Faculty of Medicine of the TU DresdenFaculty of Medicine of the TU DresdenFaculty of Medicine of the TU DresdenFaculty of Medicine of the TU DresdenFaculty of Medicine of the TU DresdenFaculty of Medicine of the TU DresdenFaculty of Medicine of the TU DresdenUniversity Hospital Carl Gustav CarusFaculty of Medicine of the TU DresdenOtto v. Guericke UniversityLeibniz Insitute for NeurobiologyFaculty of Medicine of the TU DresdenFaculty of Medicine of the TU DresdenMassachusetts General HospitalMassachusetts General HospitalThe etiology of anorexia nervosa (AN) is poorly understood. Results from functional brain imaging studies investigating the neural profile of AN using cognitive and emotional task paradigms are difficult to reconcile. Task-related imaging studies often require a high level of compliance and can only partially explore the distributed nature and complexity of brain function. In this study, resting state functional connectivity imaging was used to investigate well-characterized brain networks potentially relevant to understand the neural mechanisms underlying the symptomatology and etiology of AN. Resting state functional magnetic resonance imaging data was obtained from 35 unmedicated female acute AN patients and 35 closely matched healthy female participants (HC) and decomposed using spatial group independent component analyses. Using validated templates, we identified components covering the fronto-parietal control network, the default mode network (DMN), the salience network, the visual and the sensory-motor network. Group comparison revealed an increased functional connectivity between the angular gyrus and the other parts of the fronto-parietal network in patients with AN in comparison to HC. Connectivity of the angular gyrus was positively associated with self-reported persistence in HC. In the DMN, AN patients also showed an increased functional connectivity strength in the anterior insula in comparison to HC. Anterior insula connectivity was associated with self-reported problems with interoceptive awareness. This study, with one of the largest sample to date, shows that acute AN is associated with abnormal brain connectivity in two major resting state networks. The finding of an increased functional connectivity in the fronto-parietal network adds novel support for the notion of AN as a disorder of excessive cognitive control, whereas the elevated functional connectivity of the anterior insula with the DMN may reflect the high levels of self- and body-focushttp://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00346/fullAnorexia Nervosacognitive controlconnectivityfMRIresting stateinsula |
| spellingShingle | Ilka eBoehm Daniel eGeisler Joseph A King Franziska eRitschel Maria eSeidel Yacila eDaza Araujo Juliane ePetermann Heidi eLohmeier Jessika eWeiss Martin eWalter Martin eWalter Veit eRoessner Stefan eEhrlich Stefan eEhrlich Stefan eEhrlich Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa Frontiers in Behavioral Neuroscience Anorexia Nervosa cognitive control connectivity fMRI resting state insula |
| title | Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa |
| title_full | Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa |
| title_fullStr | Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa |
| title_full_unstemmed | Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa |
| title_short | Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa |
| title_sort | increased resting state functional connectivity in the fronto parietal and default mode network in anorexia nervosa |
| topic | Anorexia Nervosa cognitive control connectivity fMRI resting state insula |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00346/full |
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