Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study
AimRetinopathy of prematurity (ROP) is a biphasic vaso-proliferative disease that has the potential to cause blindness. In addition to prematurity and hyperoxia, perinatal infection and inflammation have been reported to play a critical role in the pathogenesis of ROP. The aim of this study was to a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1099614/full |
| _version_ | 1797896522265788416 |
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| author | Sam Ebenezer Athikarisamy Sam Ebenezer Athikarisamy Geoffrey C. Lam Geoffrey C. Lam Matthew N. Cooper Tobias Strunk Tobias Strunk Tobias Strunk |
| author_facet | Sam Ebenezer Athikarisamy Sam Ebenezer Athikarisamy Geoffrey C. Lam Geoffrey C. Lam Matthew N. Cooper Tobias Strunk Tobias Strunk Tobias Strunk |
| author_sort | Sam Ebenezer Athikarisamy |
| collection | DOAJ |
| description | AimRetinopathy of prematurity (ROP) is a biphasic vaso-proliferative disease that has the potential to cause blindness. In addition to prematurity and hyperoxia, perinatal infection and inflammation have been reported to play a critical role in the pathogenesis of ROP. The aim of this study was to assess the association between placental inflammation and the severity of ROP.MethodsA retrospective study of infants (<30 weeks of gestational age) born at the King Edward Memorial Hospital, a tertiary perinatal center in Western Australia.ResultsA total of 878 infants were included in this study (ROP stage 0–2 = 829; 3 or more = 49). The presence of maternal chorioamnionitis appeared to show signs of an association with reduced odds of severe ROP: mild chorioamnionitis OR=0.43 (95% CI: 0.17, 1.05) and severe chorioamnionitis OR=0.68 (95% CI: 0.29, 1.60). A strong association was observed for oxygen supplementation at 36 weeks (OR: 5.16; p < 0.001), exposure to postnatal steroids (OR: 6.65; p < 0.001), and receipt of platelet transfusion (OR: 8.21; p < 0.001).ConclusionMaternal chorioamnionitis or fetal chorioamnionitis was associated with reduced odds of severe ROP. A strong association was found in infants who needed oxygen supplementation at 36 weeks and those who required steroids or platelets in the postnatal period. |
| first_indexed | 2024-04-10T07:43:10Z |
| format | Article |
| id | doaj.art-3864d93f5e6d42bc9af220fbb22c1321 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T07:43:10Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-3864d93f5e6d42bc9af220fbb22c13212023-02-23T11:10:52ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-02-011110.3389/fped.2023.10996141099614Retinopathy of prematurity and placental histopathology findings: A retrospective cohort studySam Ebenezer Athikarisamy0Sam Ebenezer Athikarisamy1Geoffrey C. Lam2Geoffrey C. Lam3Matthew N. Cooper4Tobias Strunk5Tobias Strunk6Tobias Strunk7Neonatal Directorate, Child and Adolescent Health Service, Perth, WA, AustraliaSchool of Medicine, University of Western Australia, Crawley, WA, AustraliaDepartment of Ophthalmology, Perth Children’s Hospital, Perth, WA, AustraliaCentre for Ophthalmology and Visual Science, University of Western Australia, Crawley, WA, AustraliaWesfarmers' Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, WA, AustraliaNeonatal Directorate, Child and Adolescent Health Service, Perth, WA, AustraliaSchool of Medicine, University of Western Australia, Crawley, WA, AustraliaWesfarmers' Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, WA, AustraliaAimRetinopathy of prematurity (ROP) is a biphasic vaso-proliferative disease that has the potential to cause blindness. In addition to prematurity and hyperoxia, perinatal infection and inflammation have been reported to play a critical role in the pathogenesis of ROP. The aim of this study was to assess the association between placental inflammation and the severity of ROP.MethodsA retrospective study of infants (<30 weeks of gestational age) born at the King Edward Memorial Hospital, a tertiary perinatal center in Western Australia.ResultsA total of 878 infants were included in this study (ROP stage 0–2 = 829; 3 or more = 49). The presence of maternal chorioamnionitis appeared to show signs of an association with reduced odds of severe ROP: mild chorioamnionitis OR=0.43 (95% CI: 0.17, 1.05) and severe chorioamnionitis OR=0.68 (95% CI: 0.29, 1.60). A strong association was observed for oxygen supplementation at 36 weeks (OR: 5.16; p < 0.001), exposure to postnatal steroids (OR: 6.65; p < 0.001), and receipt of platelet transfusion (OR: 8.21; p < 0.001).ConclusionMaternal chorioamnionitis or fetal chorioamnionitis was associated with reduced odds of severe ROP. A strong association was found in infants who needed oxygen supplementation at 36 weeks and those who required steroids or platelets in the postnatal period.https://www.frontiersin.org/articles/10.3389/fped.2023.1099614/fullretinopathy of prematuritychorioamnionitisfunisitisinflammationoxygen |
| spellingShingle | Sam Ebenezer Athikarisamy Sam Ebenezer Athikarisamy Geoffrey C. Lam Geoffrey C. Lam Matthew N. Cooper Tobias Strunk Tobias Strunk Tobias Strunk Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study Frontiers in Pediatrics retinopathy of prematurity chorioamnionitis funisitis inflammation oxygen |
| title | Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study |
| title_full | Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study |
| title_fullStr | Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study |
| title_full_unstemmed | Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study |
| title_short | Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study |
| title_sort | retinopathy of prematurity and placental histopathology findings a retrospective cohort study |
| topic | retinopathy of prematurity chorioamnionitis funisitis inflammation oxygen |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1099614/full |
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