High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain

High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain

Abstract Background Neuroinflammation is an important driver of acute and chronic pain states. Therefore, targeting molecular mediators of neuroinflammation may present an opportunity for developing novel pain therapies. In preclinical models of neuroinflammatory pain, calcitonin gene-related peptid...

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Bibliographic Details
Main Authors: Huan Yang, Timir Datta-Chaudhuri, Sam J. George, Bilal Haider, Jason Wong, Tyler D. Hepler, Ulf Andersson, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Bioelectronic Medicine
Subjects:
Pain
Inflammation
Nerve stimulation
HMGB1
CGRP
Substance P
Online Access:https://doi.org/10.1186/s42234-022-00098-8

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