Spatiotemporal specificity of contrast adaptation in mouse primary visual cortex
Prolonged viewing of high contrast gratings alters perceived stimulus contrast, and produces characteristic changes in the contrast response functions of neurons in the primary visual cortex (V1). This is referred to as contrast adaptation. Although contrast adaptation has been well studied, its und...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-10-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00154/full |
| _version_ | 1811230426531889152 |
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| author | Emily Elizabeth LeDue Jill L King Kurt R Stover Nathan A Crowder |
| author_facet | Emily Elizabeth LeDue Jill L King Kurt R Stover Nathan A Crowder |
| author_sort | Emily Elizabeth LeDue |
| collection | DOAJ |
| description | Prolonged viewing of high contrast gratings alters perceived stimulus contrast, and produces characteristic changes in the contrast response functions of neurons in the primary visual cortex (V1). This is referred to as contrast adaptation. Although contrast adaptation has been well studied, its underlying neural mechanisms are not well understood. Therefore, we investigated contrast adaptation in mouse V1 with the goal of establishing a quantitative description of this phenomenon in a genetically manipulable animal model. One interesting aspect of contrast adaptation that has been observed both perceptually and in single unit studies is its specificity for the spatial and temporal characteristics of the stimulus. Therefore in the present work we determined if the magnitude of contrast adaptation in mouse V1 neurons was dependent on the spatial frequency and temporal frequency of the adapting grating. We used protocols that were readily comparable with previous studies in cats and primates, and also a novel contrast ramp stimulus that characterized the spatial and temporal specificity of contrast adaptation simultaneously. Similar to previous work in higher mammals, we found that contrast adaptation was strongest when the spatial frequency and temporal frequency of the adapting grating matched the test stimulus. This suggests similar mechanisms underlying contrast adaptation across animal models and indicates that the rapidly advancing genetic tools available in mice could be used to provide insights into this phenomenon. |
| first_indexed | 2024-04-12T10:29:07Z |
| format | Article |
| id | doaj.art-3866e287a2ae43b0b7331c2f68761108 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-04-12T10:29:07Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-3866e287a2ae43b0b7331c2f687611082022-12-22T03:36:53ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102013-10-01710.3389/fncir.2013.0015462395Spatiotemporal specificity of contrast adaptation in mouse primary visual cortexEmily Elizabeth LeDue0Jill L King1Kurt R Stover2Nathan A Crowder3Dalhousie UniversityDalhousie UniversityDalhousie UniversityDalhousie UniversityProlonged viewing of high contrast gratings alters perceived stimulus contrast, and produces characteristic changes in the contrast response functions of neurons in the primary visual cortex (V1). This is referred to as contrast adaptation. Although contrast adaptation has been well studied, its underlying neural mechanisms are not well understood. Therefore, we investigated contrast adaptation in mouse V1 with the goal of establishing a quantitative description of this phenomenon in a genetically manipulable animal model. One interesting aspect of contrast adaptation that has been observed both perceptually and in single unit studies is its specificity for the spatial and temporal characteristics of the stimulus. Therefore in the present work we determined if the magnitude of contrast adaptation in mouse V1 neurons was dependent on the spatial frequency and temporal frequency of the adapting grating. We used protocols that were readily comparable with previous studies in cats and primates, and also a novel contrast ramp stimulus that characterized the spatial and temporal specificity of contrast adaptation simultaneously. Similar to previous work in higher mammals, we found that contrast adaptation was strongest when the spatial frequency and temporal frequency of the adapting grating matched the test stimulus. This suggests similar mechanisms underlying contrast adaptation across animal models and indicates that the rapidly advancing genetic tools available in mice could be used to provide insights into this phenomenon.http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00154/fullElectrophysiologyadaptationcontextprimary visual cortexmouse visionsinusoidal gratings |
| spellingShingle | Emily Elizabeth LeDue Jill L King Kurt R Stover Nathan A Crowder Spatiotemporal specificity of contrast adaptation in mouse primary visual cortex Frontiers in Neural Circuits Electrophysiology adaptation context primary visual cortex mouse vision sinusoidal gratings |
| title | Spatiotemporal specificity of contrast adaptation in mouse primary visual cortex |
| title_full | Spatiotemporal specificity of contrast adaptation in mouse primary visual cortex |
| title_fullStr | Spatiotemporal specificity of contrast adaptation in mouse primary visual cortex |
| title_full_unstemmed | Spatiotemporal specificity of contrast adaptation in mouse primary visual cortex |
| title_short | Spatiotemporal specificity of contrast adaptation in mouse primary visual cortex |
| title_sort | spatiotemporal specificity of contrast adaptation in mouse primary visual cortex |
| topic | Electrophysiology adaptation context primary visual cortex mouse vision sinusoidal gratings |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00154/full |
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