Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar Rats
Low endogenous estrogen action causes several injuries. Medicinal plants, such as flaxseed and mulberry, contain substances that have been shown to be effective to the organism. The aim was to verify the effects of flaxseed and/or mulberry extracts on ovariectomized Wistar rats. The animals received...
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| author | Jéssica Petrine Castro Pereira Erika Aparecida Oliveira Fernanda Aparecida Castro Pereira Josilene Nascimento Seixas Camila Souza de Oliveira Guimaraes Bruno Del Bianco Borges |
| author_facet | Jéssica Petrine Castro Pereira Erika Aparecida Oliveira Fernanda Aparecida Castro Pereira Josilene Nascimento Seixas Camila Souza de Oliveira Guimaraes Bruno Del Bianco Borges |
| author_sort | Jéssica Petrine Castro Pereira |
| collection | DOAJ |
| description | Low endogenous estrogen action causes several injuries. Medicinal plants, such as flaxseed and mulberry, contain substances that have been shown to be effective to the organism. The aim was to verify the effects of flaxseed and/or mulberry extracts on ovariectomized Wistar rats. The animals received supplements of extracts and estrogen or saline by gavage for 60 days and were weighed weekly. Vaginal wash, blood, pituitary, uterus, liver, and kidneys were collected. Phenolic compounds and the antioxidant activity of the extracts, lipid profile, uric acid, liver enzymes, and pituitary weight were measured. Histomorphometric for uterine wall and histopathological analyses for liver and kidney were performed. Flaxseed and mulberry extracts showed great antioxidant activity and large amounts of phenolic compounds. The treatment with extracts had less weight gain, increased pituitary weight, the predominance of vaginal epithelial cells, and reduced TC, LDL-c and lipase activity, similar to estrogen animals. Estrogen or flaxseed + mulberry animals reduced VLDL-c and TAG. HDL-c, uric acid, and liver enzymes did not differ. Estrogen or extracts demonstrated trophic action on the endometrial thickness and have not shown hepatotoxicity or nephrotoxicity. We suggested the beneficial effects of flaxseed and mulberry extract as an alternative to reduce and/or prevent the negative effects caused by low estrogenic action. |
| first_indexed | 2024-03-09T05:05:50Z |
| format | Article |
| id | doaj.art-3866e5cb894247318bb9b0620aab989a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T05:05:50Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3866e5cb894247318bb9b0620aab989a2023-12-03T12:54:28ZengMDPI AGNutrients2072-66432022-08-011415323810.3390/nu14153238Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar RatsJéssica Petrine Castro Pereira0Erika Aparecida Oliveira1Fernanda Aparecida Castro Pereira2Josilene Nascimento Seixas3Camila Souza de Oliveira Guimaraes4Bruno Del Bianco Borges5Department of Medicine, Federal University of Lavras, Lavras 37200-000, MG, BrazilDepartment of Medicine, Federal University of Lavras, Lavras 37200-000, MG, BrazilDepartment of Biology, Federal University of Lavras, Lavras 37200-000, MG, BrazilDepartment of Medicine, Federal University of Lavras, Lavras 37200-000, MG, BrazilDepartment of Medicine, Federal University of Lavras, Lavras 37200-000, MG, BrazilDepartment of Medicine, Federal University of Lavras, Lavras 37200-000, MG, BrazilLow endogenous estrogen action causes several injuries. Medicinal plants, such as flaxseed and mulberry, contain substances that have been shown to be effective to the organism. The aim was to verify the effects of flaxseed and/or mulberry extracts on ovariectomized Wistar rats. The animals received supplements of extracts and estrogen or saline by gavage for 60 days and were weighed weekly. Vaginal wash, blood, pituitary, uterus, liver, and kidneys were collected. Phenolic compounds and the antioxidant activity of the extracts, lipid profile, uric acid, liver enzymes, and pituitary weight were measured. Histomorphometric for uterine wall and histopathological analyses for liver and kidney were performed. Flaxseed and mulberry extracts showed great antioxidant activity and large amounts of phenolic compounds. The treatment with extracts had less weight gain, increased pituitary weight, the predominance of vaginal epithelial cells, and reduced TC, LDL-c and lipase activity, similar to estrogen animals. Estrogen or flaxseed + mulberry animals reduced VLDL-c and TAG. HDL-c, uric acid, and liver enzymes did not differ. Estrogen or extracts demonstrated trophic action on the endometrial thickness and have not shown hepatotoxicity or nephrotoxicity. We suggested the beneficial effects of flaxseed and mulberry extract as an alternative to reduce and/or prevent the negative effects caused by low estrogenic action.https://www.mdpi.com/2072-6643/14/15/3238phytoestrogensantioxidantsestrogencompound phenolicsmetabolismbody weight |
| spellingShingle | Jéssica Petrine Castro Pereira Erika Aparecida Oliveira Fernanda Aparecida Castro Pereira Josilene Nascimento Seixas Camila Souza de Oliveira Guimaraes Bruno Del Bianco Borges Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar Rats Nutrients phytoestrogens antioxidants estrogen compound phenolics metabolism body weight |
| title | Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar Rats |
| title_full | Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar Rats |
| title_fullStr | Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar Rats |
| title_full_unstemmed | Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar Rats |
| title_short | Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar Rats |
| title_sort | beneficial effects of flaxseed and or mulberry extracts supplementation in ovariectomized wistar rats |
| topic | phytoestrogens antioxidants estrogen compound phenolics metabolism body weight |
| url | https://www.mdpi.com/2072-6643/14/15/3238 |
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