A-Scan Parameters and the Risk of Phacomorphic Glaucoma in the Kazakh Population
<i>Background and Objectives:</i> The aim of our study was to identify risk factors associated with phacomorphic glaucoma (PG) by comparing the biometric parameters of contralateral eyes of patients with PG with the eyes of patients with a mature cataract. <i>Methods</i>: Thi...
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MDPI AG
2022-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/11/1544 |
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| author | Farida Erkulovna Zhumageldiyeva Zaure Dzhumataeva Daniyar Dauletbekov Marat Suleymenov Zauresh Utelbayeva Zhanar Meyermanova Tynyskul Teleuova |
| author_facet | Farida Erkulovna Zhumageldiyeva Zaure Dzhumataeva Daniyar Dauletbekov Marat Suleymenov Zauresh Utelbayeva Zhanar Meyermanova Tynyskul Teleuova |
| author_sort | Farida Erkulovna Zhumageldiyeva |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> The aim of our study was to identify risk factors associated with phacomorphic glaucoma (PG) by comparing the biometric parameters of contralateral eyes of patients with PG with the eyes of patients with a mature cataract. <i>Methods</i>: This retrospective case–control study included 71 eyes affected with PG, 311 eyes of control participants, and 71 contralateral eyes of patients with PG. All participants were ethnically Kazakh. Axial lengths (AL), anterior chamber depths (ACD), and lens thicknesses (LT) were measured using A-scan ultrasound biometry. To determine the threshold value of the A-scan parameters associated with PG, we performed ROC analysis. <i>Results</i>: The eyes with PG had smaller AL and ACD values and larger LT values, followed by the fellow eyes with PG and the control eyes. There were no differences in age and sex between patients with PG and mature cataracts. After adjustment for age and other A-scan parameters, continuous measures of ACD and LT were associated with PG (OR 0.57, 95% CI 0.38–0.73, <i>p</i> < 0.001; OR 3.36, 95% CI 1.64–6.912, <i>p</i> = 0.001). When A-scan parameters were dichotomized according to the identified threshold, an ACD of less than 2.5 mm (OR 3.113, 95% CI 1.562–6.204, <i>p</i> = 0.001) and an LT thicker than 4.75 mm (OR 26.368, 95% CI 9.130–76.158, <i>p</i> < 0.001) were found to be related to PG. <i>Conclusions:</i> We found that a thicker lens and, possibly, a shallow ACD are risk factors for PG. |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T18:51:42Z |
| publishDate | 2022-10-01 |
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| spelling | doaj.art-3867bd9f5f69437ea0685b4e145b3d092023-11-24T05:46:33ZengMDPI AGMedicina1010-660X1648-91442022-10-015811154410.3390/medicina58111544A-Scan Parameters and the Risk of Phacomorphic Glaucoma in the Kazakh PopulationFarida Erkulovna Zhumageldiyeva0Zaure Dzhumataeva1Daniyar Dauletbekov2Marat Suleymenov3Zauresh Utelbayeva4Zhanar Meyermanova5Tynyskul Teleuova6Department of Ophthalmology, S.D. Asfendiyarov Kazakh National Medical University, Tolebe 94, Almaty 050000, KazakhstanDepartment of Functional Diagnostics, Kazakh Research Institute of Eye Diseases, Tolebe 95A, Almaty 050012, KazakhstanInstitute for Ophthalmic Research, University of Tübingen, Elfriede-Aulhorn-Strasse 7D-72076, 72074 Tübingen, GermanyDepartment of Ophthalmology, S.D. Asfendiyarov Kazakh National Medical University, Tolebe 94, Almaty 050000, KazakhstanDepartment of Ophthalmology, S.D. Asfendiyarov Kazakh National Medical University, Tolebe 94, Almaty 050000, KazakhstanDepartment of Ophthalmology, S.D. Asfendiyarov Kazakh National Medical University, Tolebe 94, Almaty 050000, KazakhstanDepartment of Ophthalmology, S.D. Asfendiyarov Kazakh National Medical University, Tolebe 94, Almaty 050000, Kazakhstan<i>Background and Objectives:</i> The aim of our study was to identify risk factors associated with phacomorphic glaucoma (PG) by comparing the biometric parameters of contralateral eyes of patients with PG with the eyes of patients with a mature cataract. <i>Methods</i>: This retrospective case–control study included 71 eyes affected with PG, 311 eyes of control participants, and 71 contralateral eyes of patients with PG. All participants were ethnically Kazakh. Axial lengths (AL), anterior chamber depths (ACD), and lens thicknesses (LT) were measured using A-scan ultrasound biometry. To determine the threshold value of the A-scan parameters associated with PG, we performed ROC analysis. <i>Results</i>: The eyes with PG had smaller AL and ACD values and larger LT values, followed by the fellow eyes with PG and the control eyes. There were no differences in age and sex between patients with PG and mature cataracts. After adjustment for age and other A-scan parameters, continuous measures of ACD and LT were associated with PG (OR 0.57, 95% CI 0.38–0.73, <i>p</i> < 0.001; OR 3.36, 95% CI 1.64–6.912, <i>p</i> = 0.001). When A-scan parameters were dichotomized according to the identified threshold, an ACD of less than 2.5 mm (OR 3.113, 95% CI 1.562–6.204, <i>p</i> = 0.001) and an LT thicker than 4.75 mm (OR 26.368, 95% CI 9.130–76.158, <i>p</i> < 0.001) were found to be related to PG. <i>Conclusions:</i> We found that a thicker lens and, possibly, a shallow ACD are risk factors for PG.https://www.mdpi.com/1648-9144/58/11/1544phacomorphic glaucomamature cataractanterior chamberaxial lengthlens |
| spellingShingle | Farida Erkulovna Zhumageldiyeva Zaure Dzhumataeva Daniyar Dauletbekov Marat Suleymenov Zauresh Utelbayeva Zhanar Meyermanova Tynyskul Teleuova A-Scan Parameters and the Risk of Phacomorphic Glaucoma in the Kazakh Population Medicina phacomorphic glaucoma mature cataract anterior chamber axial length lens |
| title | A-Scan Parameters and the Risk of Phacomorphic Glaucoma in the Kazakh Population |
| title_full | A-Scan Parameters and the Risk of Phacomorphic Glaucoma in the Kazakh Population |
| title_fullStr | A-Scan Parameters and the Risk of Phacomorphic Glaucoma in the Kazakh Population |
| title_full_unstemmed | A-Scan Parameters and the Risk of Phacomorphic Glaucoma in the Kazakh Population |
| title_short | A-Scan Parameters and the Risk of Phacomorphic Glaucoma in the Kazakh Population |
| title_sort | a scan parameters and the risk of phacomorphic glaucoma in the kazakh population |
| topic | phacomorphic glaucoma mature cataract anterior chamber axial length lens |
| url | https://www.mdpi.com/1648-9144/58/11/1544 |
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