GeneXpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of Genital Tuberculosis
Objective: The aim of this study was to find out the GeneXpert positivity among endometrial biopsy specimens for diagnosis of genital tuberculosis. Materials and Methods: A retrospective study was conducted from January 2019 to June 2019 on all women clinically and radiologically diagnosed with infe...
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| Format: | Article |
| Language: | English |
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Barpeta Obstetrics and Gynaecological Society
2020-01-01
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| Series: | New Indian Journal of OBGYN |
| Subjects: | |
| Online Access: | https://journal.barpetaogs.co.in/pdf/06119.pdf |
| _version_ | 1818316581689622528 |
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| author | Bineeta Kashyap Dibyashree Rituparna Saha N. P. Singh Puneeta Hyanki Ashwani Khanna |
| author_facet | Bineeta Kashyap Dibyashree Rituparna Saha N. P. Singh Puneeta Hyanki Ashwani Khanna |
| author_sort | Bineeta Kashyap |
| collection | DOAJ |
| description | Objective: The aim of this study was to find out the GeneXpert positivity among endometrial biopsy specimens for diagnosis of genital tuberculosis. Materials and Methods: A retrospective study was conducted from January 2019 to June 2019 on all women clinically and radiologically diagnosed with infertility, dyspareunia, menstrual irregularities and pelvic inflammatory disease. Endometrial biopsies were taken from all cases and subjected to GeneXpert test for detection of Mycobacterium tuberculosis. Result: Total number of suspected cases was 62 with age ranging from 19 years to 65 years. Majority of suspected cases were from the age group 21-30 years (54.8%). Five out of 62 (8%) cases tested positive for Mycobacterium tuberculosis by GeneXpert which were all sensitive to Rifampicin. Among these 5 cases, 2 were reported as medium positive and 3 as very low positive based on cycle threshold value. Conclusion: GeneXpert on endometrial biopsy may prove to be a reliable diagnostic modality for genital tuberculosis as well as multidrug resistance tuberculosis in females leading to timely management of the disease. |
| first_indexed | 2024-12-13T09:23:43Z |
| format | Article |
| id | doaj.art-3868ff4f83a24b478275a2d4a1771bdc |
| institution | Directory Open Access Journal |
| issn | 2454-2334 2454-2342 |
| language | English |
| last_indexed | 2024-12-13T09:23:43Z |
| publishDate | 2020-01-01 |
| publisher | Barpeta Obstetrics and Gynaecological Society |
| record_format | Article |
| series | New Indian Journal of OBGYN |
| spelling | doaj.art-3868ff4f83a24b478275a2d4a1771bdc2022-12-21T23:52:41ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422020-01-016211912210.21276/obgyn.2020.6.2.11GeneXpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of Genital TuberculosisBineeta Kashyap0Dibyashree1Rituparna Saha2 N. P. Singh3Puneeta Hyanki4Ashwani Khanna5Associate Professor, Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New DelhiPost Graduate Student, Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New DelhiSenior Resident, Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New DelhiDirector Professor and Head, Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New DelhiCMO I/C, DOTS center, University College of Medical Sciences and Guru Teg Bahadur Hospital, New DelhiState TB Officer, RNTCP, New DelhiObjective: The aim of this study was to find out the GeneXpert positivity among endometrial biopsy specimens for diagnosis of genital tuberculosis. Materials and Methods: A retrospective study was conducted from January 2019 to June 2019 on all women clinically and radiologically diagnosed with infertility, dyspareunia, menstrual irregularities and pelvic inflammatory disease. Endometrial biopsies were taken from all cases and subjected to GeneXpert test for detection of Mycobacterium tuberculosis. Result: Total number of suspected cases was 62 with age ranging from 19 years to 65 years. Majority of suspected cases were from the age group 21-30 years (54.8%). Five out of 62 (8%) cases tested positive for Mycobacterium tuberculosis by GeneXpert which were all sensitive to Rifampicin. Among these 5 cases, 2 were reported as medium positive and 3 as very low positive based on cycle threshold value. Conclusion: GeneXpert on endometrial biopsy may prove to be a reliable diagnostic modality for genital tuberculosis as well as multidrug resistance tuberculosis in females leading to timely management of the disease.https://journal.barpetaogs.co.in/pdf/06119.pdfgenebiopsytuberculosis |
| spellingShingle | Bineeta Kashyap Dibyashree Rituparna Saha N. P. Singh Puneeta Hyanki Ashwani Khanna GeneXpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of Genital Tuberculosis New Indian Journal of OBGYN gene biopsy tuberculosis |
| title | GeneXpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of Genital Tuberculosis |
| title_full | GeneXpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of Genital Tuberculosis |
| title_fullStr | GeneXpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of Genital Tuberculosis |
| title_full_unstemmed | GeneXpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of Genital Tuberculosis |
| title_short | GeneXpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of Genital Tuberculosis |
| title_sort | genexpert positivity and evaluation of rifampicin resistance among endometrial biopsy specimens for the diagnosis of genital tuberculosis |
| topic | gene biopsy tuberculosis |
| url | https://journal.barpetaogs.co.in/pdf/06119.pdf |
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