Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015–2019
In South Africa, uncomplicated community-acquired UTIs (CA-UTIs) are treated empirically; however, the extent of antibiotic resistance among these pathogens is not well known. We conducted a descriptive cross-sectional study of women attending ANCs at four tertiary public-sector hospitals in Gauteng...
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MDPI AG
2021-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/6/669 |
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| author | Thembekile Zwane Liliwe Shuping Olga Perovic |
| author_facet | Thembekile Zwane Liliwe Shuping Olga Perovic |
| author_sort | Thembekile Zwane |
| collection | DOAJ |
| description | In South Africa, uncomplicated community-acquired UTIs (CA-UTIs) are treated empirically; however, the extent of antibiotic resistance among these pathogens is not well known. We conducted a descriptive cross-sectional study of women attending ANCs at four tertiary public-sector hospitals in Gauteng. Female patients aged 15–49 years, with urine cultures performed between January 2015 and December 2019, were included. A case of culture-confirmed UTI was defined as any woman with ≤2 uropathogens with a bacterial count of ≥105 colony-forming units per ml for at least one pathogen. We identified 3558 cases of culture-confirmed UTIs in women with a median age of 30 years (interquartile range; 25–35). <i>E. coli</i> accounted for most infections (56% (1994/3558)), followed by <i>E. faecalis,</i> with a prevalence of 17% (609/3558). The prevalence of <i>K. pneumoniae</i> was 5% (193/3558), 5% (186/3558) for <i>S. agalactiae,</i> and 5% (179/3558) for <i>P. mirabilis</i>. Ninety-five percent (1827/1927) of the <i>E. coli</i> and 99% of the <i>E. faecalis</i> (301/305) isolates were susceptible to nitrofurantoin. Common uropathogens showed high susceptibility to first-line antibiotics, gentamicin and nitrofurantoin, as recommended for use in primary healthcare settings. Overall, our study provided an indication of the level of antimicrobial resistance in the four facilities. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T10:43:46Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
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| series | Antibiotics |
| spelling | doaj.art-386b6f2eb15b44ba81ac8f96e34e116b2023-11-21T22:44:42ZengMDPI AGAntibiotics2079-63822021-06-0110666910.3390/antibiotics10060669Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015–2019Thembekile Zwane0Liliwe Shuping1Olga Perovic2Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Private Bag 3 Wits, Johannesburg 2050, South AfricaCentre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, Division of the National Health Laboratory Service, Private Bag X4 Sandringham, Johannesburg 2131, South AfricaCentre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, Division of the National Health Laboratory Service, Private Bag X4 Sandringham, Johannesburg 2131, South AfricaIn South Africa, uncomplicated community-acquired UTIs (CA-UTIs) are treated empirically; however, the extent of antibiotic resistance among these pathogens is not well known. We conducted a descriptive cross-sectional study of women attending ANCs at four tertiary public-sector hospitals in Gauteng. Female patients aged 15–49 years, with urine cultures performed between January 2015 and December 2019, were included. A case of culture-confirmed UTI was defined as any woman with ≤2 uropathogens with a bacterial count of ≥105 colony-forming units per ml for at least one pathogen. We identified 3558 cases of culture-confirmed UTIs in women with a median age of 30 years (interquartile range; 25–35). <i>E. coli</i> accounted for most infections (56% (1994/3558)), followed by <i>E. faecalis,</i> with a prevalence of 17% (609/3558). The prevalence of <i>K. pneumoniae</i> was 5% (193/3558), 5% (186/3558) for <i>S. agalactiae,</i> and 5% (179/3558) for <i>P. mirabilis</i>. Ninety-five percent (1827/1927) of the <i>E. coli</i> and 99% of the <i>E. faecalis</i> (301/305) isolates were susceptible to nitrofurantoin. Common uropathogens showed high susceptibility to first-line antibiotics, gentamicin and nitrofurantoin, as recommended for use in primary healthcare settings. Overall, our study provided an indication of the level of antimicrobial resistance in the four facilities.https://www.mdpi.com/2079-6382/10/6/669community-acquired urinary tract infectionantimicrobial susceptibilitymultidrug-resistant uropathogens |
| spellingShingle | Thembekile Zwane Liliwe Shuping Olga Perovic Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015–2019 Antibiotics community-acquired urinary tract infection antimicrobial susceptibility multidrug-resistant uropathogens |
| title | Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015–2019 |
| title_full | Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015–2019 |
| title_fullStr | Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015–2019 |
| title_full_unstemmed | Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015–2019 |
| title_short | Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015–2019 |
| title_sort | etiology and antimicrobial susceptibility of pathogens associated with urinary tract infections among women attending antenatal care in four south african tertiary level facilities 2015 2019 |
| topic | community-acquired urinary tract infection antimicrobial susceptibility multidrug-resistant uropathogens |
| url | https://www.mdpi.com/2079-6382/10/6/669 |
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