Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors

Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors

Abstract Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and has demonstrated clinical activity in gastric/gastro...

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Bibliographic Details
Main Authors:	Charles Caldwell, James B. Rottman, Will Paces, Elizabeth Bueche, Sofia Reitsma, Joseph Gibb, Vitria Adisetiyo, Michael S. Haas, Heidi Heath, Walter Newman, Jason Baum, Roberto Gianani, Michael H. Kagey
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-89060-3

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