Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study
Abstract: Background: Psoriasis has been associated with co-morbidities and elevated cardiovascular risk. Objectives: To analyze the relationships among metabolic syndrome, cardiovascular risk, C-reactive protein, gender, and Psoriasis severity. Methods: In this cross-sectional study, plaque Psor...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2018-03-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000200222&tlng=en |
| _version_ | 1798021347986636800 |
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| author | Renato Soriani Paschoal Daniela Antoniali Silva Renata Nahas Cardili Cacilda da Silva Souza |
| author_facet | Renato Soriani Paschoal Daniela Antoniali Silva Renata Nahas Cardili Cacilda da Silva Souza |
| author_sort | Renato Soriani Paschoal |
| collection | DOAJ |
| description | Abstract: Background: Psoriasis has been associated with co-morbidities and elevated cardiovascular risk. Objectives: To analyze the relationships among metabolic syndrome, cardiovascular risk, C-reactive protein, gender, and Psoriasis severity. Methods: In this cross-sectional study, plaque Psoriasis patients (n=90), distributed equally in gender, were analyzed according to: Psoriasis Area and Severity Index, cardiovascular risk determined by the Framingham risk score and global risk assessment, C-reactive protein and metabolic syndrome criteria (NCEPT-ATP III). Results: Metabolic syndrome frequency was 43.3% overall, without significance between genders (P=0.14); but women had higher risk for obesity (OR 2.56, 95%CI 1.02-6.41; P=0.04) and systemic arterial hypertension (OR 3.29, 95%CI 1.39-7.81; P=0.006). The increase in the Psoriasis Area and Severity Index also increased the risk for metabolic syndrome (OR 1.060, 95%CI 1.006-1.117; P=0.03). Absolute 10-year cardiovascular risk was higher in males (P=0.002), but after global risk assessment, 51.1% patients, 52.2% women, were re-classified as high-intermediate cardiovascular risk; without significance between genders (P=0.83). C-reactive protein level was elevated nearly six-fold overall, higher in metabolic syndrome (P=0.05), systemic arterial hypertension (P=0.004), and high-intermediate 10-year cardiovascular risk patients (P<0.001); positively correlated to: Framingham risk score (P<0.001; r=0.60), absolute 10-year cardiovascular risk (P<0.001; r=0.58), and age (P=0.001; r=0.35); but not to Psoriasis Area and Severity Index (P=0.14; r=0.16); increased the 10-year cardiovascular risk (R2=33.6; P<0.001), MetS risk (OR 1.17, 95%CI 0.99-1.37; P=0.05) and with age (P=0.001). HDL-cholesterol level was higher in normal C-reactive protein patients (t=1.98; P=0.05). Study limitations: Restricted sample, hospital-based and representative of a single center and no specification of psoriatic arthritis. Conclusions: Psoriasis, metabolic syndrome, systemic arterial hypertension and age share the increase in C-reactive protein, which could implicate in additional burden for increasing the cardiovascular risk and be an alert for effective interventions. |
| first_indexed | 2024-04-11T17:12:37Z |
| format | Article |
| id | doaj.art-386c12fd099e4e77a773a99d0d725276 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-11T17:12:37Z |
| publishDate | 2018-03-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-386c12fd099e4e77a773a99d0d7252762022-12-22T04:12:50ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962018-03-0193222222810.1590/abd1806-4841.20186397Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional studyRenato Soriani PaschoalDaniela Antoniali SilvaRenata Nahas CardiliCacilda da Silva SouzaAbstract: Background: Psoriasis has been associated with co-morbidities and elevated cardiovascular risk. Objectives: To analyze the relationships among metabolic syndrome, cardiovascular risk, C-reactive protein, gender, and Psoriasis severity. Methods: In this cross-sectional study, plaque Psoriasis patients (n=90), distributed equally in gender, were analyzed according to: Psoriasis Area and Severity Index, cardiovascular risk determined by the Framingham risk score and global risk assessment, C-reactive protein and metabolic syndrome criteria (NCEPT-ATP III). Results: Metabolic syndrome frequency was 43.3% overall, without significance between genders (P=0.14); but women had higher risk for obesity (OR 2.56, 95%CI 1.02-6.41; P=0.04) and systemic arterial hypertension (OR 3.29, 95%CI 1.39-7.81; P=0.006). The increase in the Psoriasis Area and Severity Index also increased the risk for metabolic syndrome (OR 1.060, 95%CI 1.006-1.117; P=0.03). Absolute 10-year cardiovascular risk was higher in males (P=0.002), but after global risk assessment, 51.1% patients, 52.2% women, were re-classified as high-intermediate cardiovascular risk; without significance between genders (P=0.83). C-reactive protein level was elevated nearly six-fold overall, higher in metabolic syndrome (P=0.05), systemic arterial hypertension (P=0.004), and high-intermediate 10-year cardiovascular risk patients (P<0.001); positively correlated to: Framingham risk score (P<0.001; r=0.60), absolute 10-year cardiovascular risk (P<0.001; r=0.58), and age (P=0.001; r=0.35); but not to Psoriasis Area and Severity Index (P=0.14; r=0.16); increased the 10-year cardiovascular risk (R2=33.6; P<0.001), MetS risk (OR 1.17, 95%CI 0.99-1.37; P=0.05) and with age (P=0.001). HDL-cholesterol level was higher in normal C-reactive protein patients (t=1.98; P=0.05). Study limitations: Restricted sample, hospital-based and representative of a single center and no specification of psoriatic arthritis. Conclusions: Psoriasis, metabolic syndrome, systemic arterial hypertension and age share the increase in C-reactive protein, which could implicate in additional burden for increasing the cardiovascular risk and be an alert for effective interventions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000200222&tlng=enCardiovascular diseasesC-reactive proteinMetabolic syndrome XPsoriasis |
| spellingShingle | Renato Soriani Paschoal Daniela Antoniali Silva Renata Nahas Cardili Cacilda da Silva Souza Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study Anais Brasileiros de Dermatologia Cardiovascular diseases C-reactive protein Metabolic syndrome X Psoriasis |
| title | Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study |
| title_full | Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study |
| title_fullStr | Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study |
| title_full_unstemmed | Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study |
| title_short | Metabolic syndrome, C-reactive protein and cardiovascular risk in psoriasis patients: a cross-sectional study |
| title_sort | metabolic syndrome c reactive protein and cardiovascular risk in psoriasis patients a cross sectional study |
| topic | Cardiovascular diseases C-reactive protein Metabolic syndrome X Psoriasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000200222&tlng=en |
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