Study on Molecular Information Intelligent Diagnosis and Treatment of Bladder Cancer on Pathological Tissue Image

BackgroundMolecular information about bladder cancer is significant for treatment and prognosis. The immunohistochemistry (IHC) method is widely used to analyze the specific biomarkers to determine molecular subtypes. However, procedures in IHC and plenty of reagents are time and labor-consuming and...

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Main Authors: Yanfeng Bai, Huogen Wang, Xuesong Wu, Menghan Weng, Qingmei Han, Liming Xu, Han Zhang, Chengdong Chang, Chaohui Jin, Ming Chen, Kunfeng Luo, Xiaodong Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.838182/full
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author Yanfeng Bai
Huogen Wang
Huogen Wang
Xuesong Wu
Menghan Weng
Qingmei Han
Liming Xu
Han Zhang
Chengdong Chang
Chaohui Jin
Ming Chen
Kunfeng Luo
Xiaodong Teng
author_facet Yanfeng Bai
Huogen Wang
Huogen Wang
Xuesong Wu
Menghan Weng
Qingmei Han
Liming Xu
Han Zhang
Chengdong Chang
Chaohui Jin
Ming Chen
Kunfeng Luo
Xiaodong Teng
author_sort Yanfeng Bai
collection DOAJ
description BackgroundMolecular information about bladder cancer is significant for treatment and prognosis. The immunohistochemistry (IHC) method is widely used to analyze the specific biomarkers to determine molecular subtypes. However, procedures in IHC and plenty of reagents are time and labor-consuming and expensive. This study established a computer-aid diagnosis system for predicting molecular subtypes, p53 status, and programmed death-ligand 1 (PD-L1) status of bladder cancer with pathological images.Materials and MethodsWe collected 119 muscle-invasive bladder cancer (MIBC) patients who underwent radical cystectomy from January 2016 to September 2018. All the pathological sections are scanned into digital whole slide images (WSIs), and the IHC results of adjacent sections were recorded as the label of the corresponding slide. The tumor areas are first segmented, then molecular subtypes, p53 status, and PD-L1 status of those tumor-positive areas would be identified by three independent convolutional neural networks (CNNs). We measured the performance of this system for predicting molecular subtypes, p53 status, and PD-L1 status of bladder cancer with accuracy, sensitivity, and specificity.ResultsFor the recognition of molecular subtypes, the accuracy is 0.94, the sensitivity is 1.00, and the specificity is 0.909. For PD-L1 status recognition, the accuracy is 0.897, the sensitivity is 0.875, and the specificity is 0.913. For p53 status recognition, the accuracy is 0.846, the sensitivity is 0.857, and the specificity is 0.750.ConclusionOur computer-aided diagnosis system can provide a novel and simple assistant tool to obtain the molecular subtype, PD-L1 status, and p53 status. It can reduce the workload of pathologists and the medical cost.
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spelling doaj.art-386c131f29bc4e718167040199006e692022-12-22T02:32:14ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.838182838182Study on Molecular Information Intelligent Diagnosis and Treatment of Bladder Cancer on Pathological Tissue ImageYanfeng Bai0Huogen Wang1Huogen Wang2Xuesong Wu3Menghan Weng4Qingmei Han5Liming Xu6Han Zhang7Chengdong Chang8Chaohui Jin9Ming Chen10Kunfeng Luo11Xiaodong Teng12Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaHithink RoyalFlush Information Network Co., Ltd., Hangzhou, ChinaCollege of Computer Science and Technology, Zhejiang University, Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaHithink RoyalFlush Information Network Co., Ltd., Hangzhou, ChinaHithink RoyalFlush Information Network Co., Ltd., Hangzhou, ChinaHithink RoyalFlush Information Network Co., Ltd., Hangzhou, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaBackgroundMolecular information about bladder cancer is significant for treatment and prognosis. The immunohistochemistry (IHC) method is widely used to analyze the specific biomarkers to determine molecular subtypes. However, procedures in IHC and plenty of reagents are time and labor-consuming and expensive. This study established a computer-aid diagnosis system for predicting molecular subtypes, p53 status, and programmed death-ligand 1 (PD-L1) status of bladder cancer with pathological images.Materials and MethodsWe collected 119 muscle-invasive bladder cancer (MIBC) patients who underwent radical cystectomy from January 2016 to September 2018. All the pathological sections are scanned into digital whole slide images (WSIs), and the IHC results of adjacent sections were recorded as the label of the corresponding slide. The tumor areas are first segmented, then molecular subtypes, p53 status, and PD-L1 status of those tumor-positive areas would be identified by three independent convolutional neural networks (CNNs). We measured the performance of this system for predicting molecular subtypes, p53 status, and PD-L1 status of bladder cancer with accuracy, sensitivity, and specificity.ResultsFor the recognition of molecular subtypes, the accuracy is 0.94, the sensitivity is 1.00, and the specificity is 0.909. For PD-L1 status recognition, the accuracy is 0.897, the sensitivity is 0.875, and the specificity is 0.913. For p53 status recognition, the accuracy is 0.846, the sensitivity is 0.857, and the specificity is 0.750.ConclusionOur computer-aided diagnosis system can provide a novel and simple assistant tool to obtain the molecular subtype, PD-L1 status, and p53 status. It can reduce the workload of pathologists and the medical cost.https://www.frontiersin.org/articles/10.3389/fmed.2022.838182/fullbladder cancermolecular informationpathologydeep learningPD-L1p53
spellingShingle Yanfeng Bai
Huogen Wang
Huogen Wang
Xuesong Wu
Menghan Weng
Qingmei Han
Liming Xu
Han Zhang
Chengdong Chang
Chaohui Jin
Ming Chen
Kunfeng Luo
Xiaodong Teng
Study on Molecular Information Intelligent Diagnosis and Treatment of Bladder Cancer on Pathological Tissue Image
Frontiers in Medicine
bladder cancer
molecular information
pathology
deep learning
PD-L1
p53
title Study on Molecular Information Intelligent Diagnosis and Treatment of Bladder Cancer on Pathological Tissue Image
title_full Study on Molecular Information Intelligent Diagnosis and Treatment of Bladder Cancer on Pathological Tissue Image
title_fullStr Study on Molecular Information Intelligent Diagnosis and Treatment of Bladder Cancer on Pathological Tissue Image
title_full_unstemmed Study on Molecular Information Intelligent Diagnosis and Treatment of Bladder Cancer on Pathological Tissue Image
title_short Study on Molecular Information Intelligent Diagnosis and Treatment of Bladder Cancer on Pathological Tissue Image
title_sort study on molecular information intelligent diagnosis and treatment of bladder cancer on pathological tissue image
topic bladder cancer
molecular information
pathology
deep learning
PD-L1
p53
url https://www.frontiersin.org/articles/10.3389/fmed.2022.838182/full
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