Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green
We recently developed a novel hyperspectral excitation-resolved near-infrared fluorescence imaging system (HER-NIRF) based on a continuous-wave wavelength-swept laser. In this study, this technique is applied to measure the distribution of the therapeutic agent dimethyl sulfoxide (DMSO) by utilizing...
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MDPI AG
2023-09-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/23/18/7728 |
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| author | Jaedu Cho Farouk Nouizi Chang-Seok Kim Gultekin Gulsen |
| author_facet | Jaedu Cho Farouk Nouizi Chang-Seok Kim Gultekin Gulsen |
| author_sort | Jaedu Cho |
| collection | DOAJ |
| description | We recently developed a novel hyperspectral excitation-resolved near-infrared fluorescence imaging system (HER-NIRF) based on a continuous-wave wavelength-swept laser. In this study, this technique is applied to measure the distribution of the therapeutic agent dimethyl sulfoxide (DMSO) by utilizing solvatochromic shift in the spectral profile of albumin-bound Indocyanine green (ICG). Using wide-field imaging in turbid media, complex dynamics of albumin-bound ICG are measured in mixtures of dimethyl sulfoxide (DMSO) and water. Phantom experiments are conducted to evaluate the performance of the HER-NIRF system. The results show that the distribution of DMSO can be visualized in the wide-field reflection geometry. One of the main purposes of the DMSO is to act as a carrier for other drugs, enhancing their effects by facilitating skin penetration. Understanding the solubility and permeability of drugs in vivo is very important in drug discovery and development. Hence, this HER-NIRF technique has great potential to advance the utilization of the therapeutic agent DMSO by mapping its distribution via the solvatochromic shift of ICG. By customizing the operational wavelength range, this system can be applied to any other fluorophores in the near-infrared region and utilized for a wide variety of drug delivery studies. |
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| format | Article |
| id | doaj.art-386dab3e4a274a089b5dfb4e0c9e882f |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T22:03:11Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-386dab3e4a274a089b5dfb4e0c9e882f2023-11-19T12:53:23ZengMDPI AGSensors1424-82202023-09-012318772810.3390/s23187728Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine GreenJaedu Cho0Farouk Nouizi1Chang-Seok Kim2Gultekin Gulsen3Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA 92697, USATu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA 92697, USADepartment of Cogno-Mechatronics Engineering, Pusan National University, Busan 607-735, Republic of KoreaTu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA 92697, USAWe recently developed a novel hyperspectral excitation-resolved near-infrared fluorescence imaging system (HER-NIRF) based on a continuous-wave wavelength-swept laser. In this study, this technique is applied to measure the distribution of the therapeutic agent dimethyl sulfoxide (DMSO) by utilizing solvatochromic shift in the spectral profile of albumin-bound Indocyanine green (ICG). Using wide-field imaging in turbid media, complex dynamics of albumin-bound ICG are measured in mixtures of dimethyl sulfoxide (DMSO) and water. Phantom experiments are conducted to evaluate the performance of the HER-NIRF system. The results show that the distribution of DMSO can be visualized in the wide-field reflection geometry. One of the main purposes of the DMSO is to act as a carrier for other drugs, enhancing their effects by facilitating skin penetration. Understanding the solubility and permeability of drugs in vivo is very important in drug discovery and development. Hence, this HER-NIRF technique has great potential to advance the utilization of the therapeutic agent DMSO by mapping its distribution via the solvatochromic shift of ICG. By customizing the operational wavelength range, this system can be applied to any other fluorophores in the near-infrared region and utilized for a wide variety of drug delivery studies.https://www.mdpi.com/1424-8220/23/18/7728fluorescence imagingmultispectral and hyperspectral imagingsolvatochromic shifttunable lasersspectroscopyDMSO sensing |
| spellingShingle | Jaedu Cho Farouk Nouizi Chang-Seok Kim Gultekin Gulsen Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green Sensors fluorescence imaging multispectral and hyperspectral imaging solvatochromic shift tunable lasers spectroscopy DMSO sensing |
| title | Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green |
| title_full | Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green |
| title_fullStr | Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green |
| title_full_unstemmed | Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green |
| title_short | Monitoring Distribution of the Therapeutic Agent Dimethyl Sulfoxide via Solvatochromic Shift of Albumin-Bound Indocyanine Green |
| title_sort | monitoring distribution of the therapeutic agent dimethyl sulfoxide via solvatochromic shift of albumin bound indocyanine green |
| topic | fluorescence imaging multispectral and hyperspectral imaging solvatochromic shift tunable lasers spectroscopy DMSO sensing |
| url | https://www.mdpi.com/1424-8220/23/18/7728 |
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