Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China
Invasive pulmonary fungal infection (IPFI) is a potentially fatal complication in patients with connective tissue disease (CTD). The current study aimed to uncover the clinical characteristics and risk factors of patients with IPFI-CTD. The files of 2186 CTD patients admitted to a single center in n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2016-09-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/bjmbr/v49n10/1414-431X-bjmbr-1414-431X20165531.pdf |
| _version_ | 1828127280188096512 |
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| author | H.F. Ge X.Q. Liu Y.Q. Zhu H.Q. Chen G.Z. Chen |
| author_facet | H.F. Ge X.Q. Liu Y.Q. Zhu H.Q. Chen G.Z. Chen |
| author_sort | H.F. Ge |
| collection | DOAJ |
| description | Invasive pulmonary fungal infection (IPFI) is a potentially fatal complication in patients with connective tissue disease (CTD). The current study aimed to uncover the clinical characteristics and risk factors of patients with IPFI-CTD. The files of 2186 CTD patients admitted to a single center in northern China between January 2011 and December 2013 were retrospectively reviewed. A total of 47 CTD patients with IPFI were enrolled into this study and assigned to the CTD-IPFI group, while 47 uninfected CTD patients were assigned to the control group. Clinical manifestations were recorded, and risk factors of IPFI were calculated by stepwise logistical regression analysis. Forty-seven (2.15%) CTD patients developed IPFI. Systemic lupus erythematosus patients were responsible for the highest proportion (36.17%) of cases with IPFI. Candida albicans (72.3%) accounted for the most common fungal species. CTD-IPFI patients had significantly elevated white blood cell count, erythrocyte sedimentation rate, C-reactive protein and fasting glucose values compared to controls (P<0.05). Cough, sputum and blood in phlegm were the most common symptoms. Risk factors of IPFI in CTD included maximum prednisone dose ≥30 mg/day within 3 months prior to infection, anti-microbial drug therapy, and interstitial pneumonia. CTD patients who have underlying interstitial pneumonia, prior prednisone or multiple antibiotics, were more likely to develop IPFI. |
| first_indexed | 2024-04-11T15:47:46Z |
| format | Article |
| id | doaj.art-38721e0866bc4abfac21bd9a670cf041 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-11T15:47:46Z |
| publishDate | 2016-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-38721e0866bc4abfac21bd9a670cf0412022-12-22T04:15:28ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2016-09-01491010.1590/1414-431x20165531Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern ChinaH.F. GeX.Q. LiuY.Q. ZhuH.Q. ChenG.Z. ChenInvasive pulmonary fungal infection (IPFI) is a potentially fatal complication in patients with connective tissue disease (CTD). The current study aimed to uncover the clinical characteristics and risk factors of patients with IPFI-CTD. The files of 2186 CTD patients admitted to a single center in northern China between January 2011 and December 2013 were retrospectively reviewed. A total of 47 CTD patients with IPFI were enrolled into this study and assigned to the CTD-IPFI group, while 47 uninfected CTD patients were assigned to the control group. Clinical manifestations were recorded, and risk factors of IPFI were calculated by stepwise logistical regression analysis. Forty-seven (2.15%) CTD patients developed IPFI. Systemic lupus erythematosus patients were responsible for the highest proportion (36.17%) of cases with IPFI. Candida albicans (72.3%) accounted for the most common fungal species. CTD-IPFI patients had significantly elevated white blood cell count, erythrocyte sedimentation rate, C-reactive protein and fasting glucose values compared to controls (P<0.05). Cough, sputum and blood in phlegm were the most common symptoms. Risk factors of IPFI in CTD included maximum prednisone dose ≥30 mg/day within 3 months prior to infection, anti-microbial drug therapy, and interstitial pneumonia. CTD patients who have underlying interstitial pneumonia, prior prednisone or multiple antibiotics, were more likely to develop IPFI.http://www.scielo.br/pdf/bjmbr/v49n10/1414-431X-bjmbr-1414-431X20165531.pdfConnective tissue diseasesInvasive pulmonary fungal infectionPulmonary diseaseRetrospective study |
| spellingShingle | H.F. Ge X.Q. Liu Y.Q. Zhu H.Q. Chen G.Z. Chen Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China Brazilian Journal of Medical and Biological Research Connective tissue diseases Invasive pulmonary fungal infection Pulmonary disease Retrospective study |
| title | Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China |
| title_full | Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China |
| title_fullStr | Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China |
| title_full_unstemmed | Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China |
| title_short | Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China |
| title_sort | invasive pulmonary fungal infections in patients with connective tissue disease a retrospective study from northern china |
| topic | Connective tissue diseases Invasive pulmonary fungal infection Pulmonary disease Retrospective study |
| url | http://www.scielo.br/pdf/bjmbr/v49n10/1414-431X-bjmbr-1414-431X20165531.pdf |
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