Prognostic Indicators for Ebola Patient Survival

Prognostic Indicators for Ebola Patient Survival

To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission an...

Full description

Bibliographic Details
Main Authors: Samuel J. Crowe, Matthew J. Maenner, Solomon Kuah, Bobbie Rae Erickson, Megan Coffee, Barbara Knust, John D. Klena, Joyce Foday, Darren Hertz, Veerle Hermans, Jay Achar, Grazia M. Caleo, Michel Van Herp, César G. Albariño, Brian Amman, Alison Jane Basile, Scott Bearden, Jessica A. Belser, Eric Bergeron, Dianna Blau, Aaron C. Brault, Shelley Campbell, Mike Flint, Aridth Gibbons, Christin Goodman, Laura McMullan, Christopher D. Paddock, Brandy Russell, Johanna S. Salzer, Angela Sanchez, Tara Sealy, David Wang, Gbessay Saffa, Alhajie Turay, Stuart T. Nichol, Jonathan S. Towner
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2016-02-01
Series:Emerging Infectious Diseases
Subjects:
Ebola virus disease
hemorrhagic fever
survival
prognosis
Sierra Leone
viruses
Online Access:https://wwwnc.cdc.gov/eid/article/22/2/15-1250_article
Description
Summary:To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus–positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus–positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations.
ISSN:1080-6040
1080-6059

Similar Items