Prognostic Indicators for Ebola Patient Survival
To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission an...
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2016-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/22/2/15-1250_article |
| _version_ | 1818242736801710080 |
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| author | Samuel J. Crowe Matthew J. Maenner Solomon Kuah Bobbie Rae Erickson Megan Coffee Barbara Knust John D. Klena Joyce Foday Darren Hertz Veerle Hermans Jay Achar Grazia M. Caleo Michel Van Herp César G. Albariño Brian Amman Alison Jane Basile Scott Bearden Jessica A. Belser Eric Bergeron Dianna Blau Aaron C. Brault Shelley Campbell Mike Flint Aridth Gibbons Christin Goodman Laura McMullan Christopher D. Paddock Brandy Russell Johanna S. Salzer Angela Sanchez Tara Sealy David Wang Gbessay Saffa Alhajie Turay Stuart T. Nichol Jonathan S. Towner |
| author_facet | Samuel J. Crowe Matthew J. Maenner Solomon Kuah Bobbie Rae Erickson Megan Coffee Barbara Knust John D. Klena Joyce Foday Darren Hertz Veerle Hermans Jay Achar Grazia M. Caleo Michel Van Herp César G. Albariño Brian Amman Alison Jane Basile Scott Bearden Jessica A. Belser Eric Bergeron Dianna Blau Aaron C. Brault Shelley Campbell Mike Flint Aridth Gibbons Christin Goodman Laura McMullan Christopher D. Paddock Brandy Russell Johanna S. Salzer Angela Sanchez Tara Sealy David Wang Gbessay Saffa Alhajie Turay Stuart T. Nichol Jonathan S. Towner |
| author_sort | Samuel J. Crowe |
| collection | DOAJ |
| description | To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus–positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus–positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations. |
| first_indexed | 2024-12-12T13:49:59Z |
| format | Article |
| id | doaj.art-38723529c7a544eb8d13c63b2ad32538 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T13:49:59Z |
| publishDate | 2016-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-38723529c7a544eb8d13c63b2ad325382022-12-22T00:22:36ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592016-02-0122221722310.3201/eid2202.151250Prognostic Indicators for Ebola Patient SurvivalSamuel J. CroweMatthew J. MaennerSolomon KuahBobbie Rae EricksonMegan CoffeeBarbara KnustJohn D. KlenaJoyce FodayDarren HertzVeerle HermansJay AcharGrazia M. CaleoMichel Van HerpCésar G. AlbariñoBrian AmmanAlison Jane BasileScott BeardenJessica A. BelserEric BergeronDianna BlauAaron C. BraultShelley CampbellMike FlintAridth GibbonsChristin GoodmanLaura McMullanChristopher D. PaddockBrandy RussellJohanna S. SalzerAngela SanchezTara SealyDavid WangGbessay SaffaAlhajie TurayStuart T. NicholJonathan S. TownerTo determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus–positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus–positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations.https://wwwnc.cdc.gov/eid/article/22/2/15-1250_articleEbola virus diseasehemorrhagic feversurvivalprognosisSierra Leoneviruses |
| spellingShingle | Samuel J. Crowe Matthew J. Maenner Solomon Kuah Bobbie Rae Erickson Megan Coffee Barbara Knust John D. Klena Joyce Foday Darren Hertz Veerle Hermans Jay Achar Grazia M. Caleo Michel Van Herp César G. Albariño Brian Amman Alison Jane Basile Scott Bearden Jessica A. Belser Eric Bergeron Dianna Blau Aaron C. Brault Shelley Campbell Mike Flint Aridth Gibbons Christin Goodman Laura McMullan Christopher D. Paddock Brandy Russell Johanna S. Salzer Angela Sanchez Tara Sealy David Wang Gbessay Saffa Alhajie Turay Stuart T. Nichol Jonathan S. Towner Prognostic Indicators for Ebola Patient Survival Emerging Infectious Diseases Ebola virus disease hemorrhagic fever survival prognosis Sierra Leone viruses |
| title | Prognostic Indicators for Ebola Patient Survival |
| title_full | Prognostic Indicators for Ebola Patient Survival |
| title_fullStr | Prognostic Indicators for Ebola Patient Survival |
| title_full_unstemmed | Prognostic Indicators for Ebola Patient Survival |
| title_short | Prognostic Indicators for Ebola Patient Survival |
| title_sort | prognostic indicators for ebola patient survival |
| topic | Ebola virus disease hemorrhagic fever survival prognosis Sierra Leone viruses |
| url | https://wwwnc.cdc.gov/eid/article/22/2/15-1250_article |
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