The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy
Abstract The development of head and neck squamous cell carcinoma (HNSCC) is a multi-step process, and its survival depends on a complex tumor ecosystem, which not only promotes tumor growth but also helps to protect tumor cells from immune surveillance. With the advances of existing technologies an...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-023-01769-z |
| _version_ | 1797850154213048320 |
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| author | Yingying Gong Lisha Bao Tong Xu Xiaofen Yi Jinming Chen Shanshan Wang Zongfu Pan Ping Huang Minghua Ge |
| author_facet | Yingying Gong Lisha Bao Tong Xu Xiaofen Yi Jinming Chen Shanshan Wang Zongfu Pan Ping Huang Minghua Ge |
| author_sort | Yingying Gong |
| collection | DOAJ |
| description | Abstract The development of head and neck squamous cell carcinoma (HNSCC) is a multi-step process, and its survival depends on a complex tumor ecosystem, which not only promotes tumor growth but also helps to protect tumor cells from immune surveillance. With the advances of existing technologies and emerging models for ecosystem research, the evidence for cell-cell interplay is increasing. Herein, we discuss the recent advances in understanding the interaction between tumor cells, the major components of the HNSCC tumor ecosystem, and summarize the mechanisms of how biological and abiotic factors affect the tumor ecosystem. In addition, we review the emerging ecological treatment strategy for HNSCC based on existing studies. |
| first_indexed | 2024-04-09T18:55:47Z |
| format | Article |
| id | doaj.art-3872ec0e1bf4434182a24a4efd5167b2 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-04-09T18:55:47Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-3872ec0e1bf4434182a24a4efd5167b22023-04-09T11:09:54ZengBMCMolecular Cancer1476-45982023-04-0122111710.1186/s12943-023-01769-zThe tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapyYingying Gong0Lisha Bao1Tong Xu2Xiaofen Yi3Jinming Chen4Shanshan Wang5Zongfu Pan6Ping Huang7Minghua Ge8Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Abstract The development of head and neck squamous cell carcinoma (HNSCC) is a multi-step process, and its survival depends on a complex tumor ecosystem, which not only promotes tumor growth but also helps to protect tumor cells from immune surveillance. With the advances of existing technologies and emerging models for ecosystem research, the evidence for cell-cell interplay is increasing. Herein, we discuss the recent advances in understanding the interaction between tumor cells, the major components of the HNSCC tumor ecosystem, and summarize the mechanisms of how biological and abiotic factors affect the tumor ecosystem. In addition, we review the emerging ecological treatment strategy for HNSCC based on existing studies.https://doi.org/10.1186/s12943-023-01769-zHead and neck squamous cell carcinomaTumor ecosystemEcological therapy |
| spellingShingle | Yingying Gong Lisha Bao Tong Xu Xiaofen Yi Jinming Chen Shanshan Wang Zongfu Pan Ping Huang Minghua Ge The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy Molecular Cancer Head and neck squamous cell carcinoma Tumor ecosystem Ecological therapy |
| title | The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy |
| title_full | The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy |
| title_fullStr | The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy |
| title_full_unstemmed | The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy |
| title_short | The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy |
| title_sort | tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy |
| topic | Head and neck squamous cell carcinoma Tumor ecosystem Ecological therapy |
| url | https://doi.org/10.1186/s12943-023-01769-z |
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