Diagnosis of Beta-Thalassaemia Carriers in the Sultanate of Oman
Background: Haemoglobinopathies are a major cause of morbidity in the Sultanate of Oman and premarital screening is being encouraged in order to reduce the number of affected births. The identification of β-thalassaemia carrier status is an essential prerequisite of any screening programme. However,...
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| Format: | Article |
| Language: | English |
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Sultan Qaboos University
2006-06-01
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| Series: | Sultan Qaboos University Medical Journal |
| Subjects: | |
| Online Access: | https://journals.squ.edu.om/index.php/squmj/article/view/1253 |
| _version_ | 1818643615760515072 |
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| author | Shahina Daar David Gravell |
| author_facet | Shahina Daar David Gravell |
| author_sort | Shahina Daar |
| collection | DOAJ |
| description | Background: Haemoglobinopathies are a major cause of morbidity in the Sultanate of Oman and premarital screening is being encouraged in order to reduce the number of affected births. The identification of β-thalassaemia carrier status is an essential prerequisite of any screening programme. However, the level of Haemoglobin (Hb) A2, which is used to detect β-thalassaemia carriers, can be affected by other factors including iron deficiency, concurrent α thalassaemia and the type of DNA mutation present. Objectives:The following study was undertaken to ascertain if the Hb A2 level is an appropriate tool for the identification of β-thalassaemia carriers in the Omani population. Method: Hb A2 was measured by high performance liquid chromatography (HPLC) in 160 obligate carriers of β-thalassaemia. 158 subjects had Hb A2 levels above 3.5% indicating β-thalassaemia trait. Two subjects had slightly lower levels and were found to be iron deficient. After therapy both these subjects’ Hb A2 levels increased to above 3.5%. Conclusion: In the absence of iron deficiency, Hb A2 is an accurate marker for the presence of β-thalassaemia trait in the Sultanate of Oman. |
| first_indexed | 2024-12-17T00:01:47Z |
| format | Article |
| id | doaj.art-3873b0fa5f2748a9996709d6c35f3db3 |
| institution | Directory Open Access Journal |
| issn | 2075-051X 2075-0528 |
| language | English |
| last_indexed | 2024-12-17T00:01:47Z |
| publishDate | 2006-06-01 |
| publisher | Sultan Qaboos University |
| record_format | Article |
| series | Sultan Qaboos University Medical Journal |
| spelling | doaj.art-3873b0fa5f2748a9996709d6c35f3db32022-12-21T22:11:03ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal2075-051X2075-05282006-06-016127311181Diagnosis of Beta-Thalassaemia Carriers in the Sultanate of OmanShahina Daar0David Gravell1Department of Haematology, Sultan Qaboos University, College of Medicine and Health Sciences, P.O.Box 35, Al-Khod, Muscat 123, Sultanate of OmanDepartment of Haematology, Sultan Qaboos University Hospital, P.O.Box 35, Al-Khod, Muscat 123, Sultanate of Oman.Background: Haemoglobinopathies are a major cause of morbidity in the Sultanate of Oman and premarital screening is being encouraged in order to reduce the number of affected births. The identification of β-thalassaemia carrier status is an essential prerequisite of any screening programme. However, the level of Haemoglobin (Hb) A2, which is used to detect β-thalassaemia carriers, can be affected by other factors including iron deficiency, concurrent α thalassaemia and the type of DNA mutation present. Objectives:The following study was undertaken to ascertain if the Hb A2 level is an appropriate tool for the identification of β-thalassaemia carriers in the Omani population. Method: Hb A2 was measured by high performance liquid chromatography (HPLC) in 160 obligate carriers of β-thalassaemia. 158 subjects had Hb A2 levels above 3.5% indicating β-thalassaemia trait. Two subjects had slightly lower levels and were found to be iron deficient. After therapy both these subjects’ Hb A2 levels increased to above 3.5%. Conclusion: In the absence of iron deficiency, Hb A2 is an accurate marker for the presence of β-thalassaemia trait in the Sultanate of Oman.https://journals.squ.edu.om/index.php/squmj/article/view/1253hb a2 , β-thalassaemia trait, sultanate of oman |
| spellingShingle | Shahina Daar David Gravell Diagnosis of Beta-Thalassaemia Carriers in the Sultanate of Oman Sultan Qaboos University Medical Journal hb a2 , β-thalassaemia trait, sultanate of oman |
| title | Diagnosis of Beta-Thalassaemia Carriers in the Sultanate of Oman |
| title_full | Diagnosis of Beta-Thalassaemia Carriers in the Sultanate of Oman |
| title_fullStr | Diagnosis of Beta-Thalassaemia Carriers in the Sultanate of Oman |
| title_full_unstemmed | Diagnosis of Beta-Thalassaemia Carriers in the Sultanate of Oman |
| title_short | Diagnosis of Beta-Thalassaemia Carriers in the Sultanate of Oman |
| title_sort | diagnosis of beta thalassaemia carriers in the sultanate of oman |
| topic | hb a2 , β-thalassaemia trait, sultanate of oman |
| url | https://journals.squ.edu.om/index.php/squmj/article/view/1253 |
| work_keys_str_mv | AT shahinadaar diagnosisofbetathalassaemiacarriersinthesultanateofoman AT davidgravell diagnosisofbetathalassaemiacarriersinthesultanateofoman |