MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies
<b>Background:</b> During orthodontic tooth movement (OTM), applied orthodontic forces cause an extensive remodeling of the extracellular matrix (ECM) in the periodontal ligament (PDL). This is mainly orchestrated by different types of matrix metalloproteinases (MMPs) and their tissue in...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/6967 |
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| author | Christian Behm Michael Nemec Fabian Weissinger Marco Aoqi Rausch Oleh Andrukhov Erwin Jonke |
| author_facet | Christian Behm Michael Nemec Fabian Weissinger Marco Aoqi Rausch Oleh Andrukhov Erwin Jonke |
| author_sort | Christian Behm |
| collection | DOAJ |
| description | <b>Background:</b> During orthodontic tooth movement (OTM), applied orthodontic forces cause an extensive remodeling of the extracellular matrix (ECM) in the periodontal ligament (PDL). This is mainly orchestrated by different types of matrix metalloproteinases (MMPs) and their tissue inhibitors of matrix metalloproteinases (TIMPs), which are both secreted by periodontal ligament (PDL) fibroblasts. Multiple in vitro and in vivo studies already investigated the influence of applied orthodontic forces on the expression of MMPs and TIMPs. The aim of this systematic review was to explore the expression levels of MMPs and TIMPs during OTM and the influence of specific orthodontic force-related parameters. <b>Methods:</b> Electronic article search was performed on PubMed and Web of Science until 31 January 2021. Screenings of titles, abstracts and full texts were performed according to PRISMA, whereas eligibility criteria were defined for in vitro and in vivo studies, respectively, according to the PICO schema. Risk of bias assessment for in vitro studies was verified by specific methodological and reporting criteria. For in vivo studies, risk of bias assessment was adapted from the Joanna Briggs Institute Critical Appraisal Checklist for analytical cross-sectional study. <b>Results:</b> Electronic article search identified 3266 records, from which 28 in vitro and 12 in vivo studies were included. The studies showed that orthodontic forces mainly caused increased MMPs and TIMPs expression levels, whereas the exact effect may depend on various intervention and sample parameters and subject characteristics. <b>Conclusion:</b> This systematic review revealed that orthodontic forces induce a significant effect on MMPs and TIMPs in the PDL. This connection may contribute to the controlled depletion and formation of the PDLs’ ECM at the compression and tension site, respectively, and finally to the highly regulated OTM. |
| first_indexed | 2024-03-10T09:59:29Z |
| format | Article |
| id | doaj.art-3875b5e12910475d9cc25afd6c7b5c59 |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:59:29Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3875b5e12910475d9cc25afd6c7b5c592023-11-22T02:04:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213696710.3390/ijms22136967MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo StudiesChristian Behm0Michael Nemec1Fabian Weissinger2Marco Aoqi Rausch3Oleh Andrukhov4Erwin Jonke5Clinical Division of Orthodontics, University Clinic of Dentistry, Sensengasse 2A, 1090 Vienna, AustriaClinical Division of Orthodontics, University Clinic of Dentistry, Sensengasse 2A, 1090 Vienna, AustriaCompetence Centre for Periodontal Research, University Clinic of Dentistry, Sensengasse 2A, 1090 Vienna, AustriaClinical Division of Orthodontics, University Clinic of Dentistry, Sensengasse 2A, 1090 Vienna, AustriaCompetence Centre for Periodontal Research, University Clinic of Dentistry, Sensengasse 2A, 1090 Vienna, AustriaClinical Division of Orthodontics, University Clinic of Dentistry, Sensengasse 2A, 1090 Vienna, Austria<b>Background:</b> During orthodontic tooth movement (OTM), applied orthodontic forces cause an extensive remodeling of the extracellular matrix (ECM) in the periodontal ligament (PDL). This is mainly orchestrated by different types of matrix metalloproteinases (MMPs) and their tissue inhibitors of matrix metalloproteinases (TIMPs), which are both secreted by periodontal ligament (PDL) fibroblasts. Multiple in vitro and in vivo studies already investigated the influence of applied orthodontic forces on the expression of MMPs and TIMPs. The aim of this systematic review was to explore the expression levels of MMPs and TIMPs during OTM and the influence of specific orthodontic force-related parameters. <b>Methods:</b> Electronic article search was performed on PubMed and Web of Science until 31 January 2021. Screenings of titles, abstracts and full texts were performed according to PRISMA, whereas eligibility criteria were defined for in vitro and in vivo studies, respectively, according to the PICO schema. Risk of bias assessment for in vitro studies was verified by specific methodological and reporting criteria. For in vivo studies, risk of bias assessment was adapted from the Joanna Briggs Institute Critical Appraisal Checklist for analytical cross-sectional study. <b>Results:</b> Electronic article search identified 3266 records, from which 28 in vitro and 12 in vivo studies were included. The studies showed that orthodontic forces mainly caused increased MMPs and TIMPs expression levels, whereas the exact effect may depend on various intervention and sample parameters and subject characteristics. <b>Conclusion:</b> This systematic review revealed that orthodontic forces induce a significant effect on MMPs and TIMPs in the PDL. This connection may contribute to the controlled depletion and formation of the PDLs’ ECM at the compression and tension site, respectively, and finally to the highly regulated OTM.https://www.mdpi.com/1422-0067/22/13/6967orthodontic tooth movementmatrix metalloproteinasestissue inhibitor of matrix metalloproteinasesperiodontal ligament |
| spellingShingle | Christian Behm Michael Nemec Fabian Weissinger Marco Aoqi Rausch Oleh Andrukhov Erwin Jonke MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies International Journal of Molecular Sciences orthodontic tooth movement matrix metalloproteinases tissue inhibitor of matrix metalloproteinases periodontal ligament |
| title | MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies |
| title_full | MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies |
| title_fullStr | MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies |
| title_full_unstemmed | MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies |
| title_short | MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies |
| title_sort | mmps and timps expression levels in the periodontal ligament during orthodontic tooth movement a systematic review of in vitro and in vivo studies |
| topic | orthodontic tooth movement matrix metalloproteinases tissue inhibitor of matrix metalloproteinases periodontal ligament |
| url | https://www.mdpi.com/1422-0067/22/13/6967 |
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