Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties

Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties

The extracellular matrix (ECM) plays an instrumental role in determining the spatial orientation of epithelial polarity and the formation of lumens in glandular tissues during morphogenesis. Here, we show that the Endoplasmic Reticulum (ER)-resident protein anterior gradient-2 (AGR2), a soluble prot...

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Bibliographic Details
Main Authors: Delphine Fessart, Charlotte Domblides, Tony Avril, Leif A Eriksson, Hugues Begueret, Raphael Pineau, Camille Malrieux, Nathalie Dugot-Senant, Carlo Lucchesi, Eric Chevet, Frederic Delom
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
AGR2
cancer
organoids
protein disulphide isomerase
endoplasmic reticulum
Online Access:https://elifesciences.org/articles/13887

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