Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients
IntroductionMultiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization. This study aims to evaluate the impact of MDR...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1044188/full |
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| author | Di Wu Di Wu Yan Jia Wenhao Cai Wenhao Cai Yilin Huang Arjun Kattakayam Diane Latawiec Robert Sutton Jie Peng |
| author_facet | Di Wu Di Wu Yan Jia Wenhao Cai Wenhao Cai Yilin Huang Arjun Kattakayam Diane Latawiec Robert Sutton Jie Peng |
| author_sort | Di Wu |
| collection | DOAJ |
| description | IntroductionMultiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization. This study aims to evaluate the impact of MDR Gram-negative bacteraemia on IPN patients.MethodsA case–control study was performed with data collected from 1 January 2016 to 1 July 2022 in a Chinese tertiary teaching hospital. Clinical data of the IPN patients with MDR-GNB bacteraemia were analyzed and compared to those of a matched control group without MDR-GNB bacteraemia (case–control ratio of 1:2). Comparisons were performed between with/without MDR-GNB bacteraemia and different severities of acute pancreatitis (AP). Independent predictors of overall mortality were identified via univariate and multivariate binary logistic regression analyses.ResultsMDR-GNB bacteraemia was related to a higher mortality rate (62.5% vs. 8.3%, p < 0.001). Severe AP combined with MDR-GNB bacteraemia further increased mortality up to 81.3% (p = 0.025). MDR-GNB bacteraemia (odds ratio (OR) = 8.976, 95% confidence interval (CI) = 1.805 –44.620, p = 0.007) and severe AP (OR = 9.414, 95% CI = 1.742 –50.873, p = 0.009) were independent predictors of overall mortality. MDR- Klebsiella pneumoniae was the most common causative pathogen.ConclusionA higher mortality rate in IPN patients was related to MDR-GNB bacteraemia and further increased in severe AP patients combined with MDR-GNB bacteraemia. |
| first_indexed | 2024-04-13T08:12:16Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T08:12:16Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-3876705839be43beb50af657bddd390d2022-12-22T02:54:55ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-11-011210.3389/fcimb.2022.10441881044188Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patientsDi Wu0Di Wu1Yan Jia2Wenhao Cai3Wenhao Cai4Yilin Huang5Arjun Kattakayam6Diane Latawiec7Robert Sutton8Jie Peng9Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, ChinaLiverpool Pancreatitis Research Group, Institute of Systems, Molecular and Integrative Biology, University of Liverpool and Liverpool University Hospitals NHS Foundation Trust, Liverpool, Merseyside, United KingdomDepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha, ChinaLiverpool Pancreatitis Research Group, Institute of Systems, Molecular and Integrative Biology, University of Liverpool and Liverpool University Hospitals NHS Foundation Trust, Liverpool, Merseyside, United KingdomWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha, ChinaLiverpool Pancreatitis Research Group, Institute of Systems, Molecular and Integrative Biology, University of Liverpool and Liverpool University Hospitals NHS Foundation Trust, Liverpool, Merseyside, United KingdomLiverpool Pancreatitis Research Group, Institute of Systems, Molecular and Integrative Biology, University of Liverpool and Liverpool University Hospitals NHS Foundation Trust, Liverpool, Merseyside, United KingdomLiverpool Pancreatitis Research Group, Institute of Systems, Molecular and Integrative Biology, University of Liverpool and Liverpool University Hospitals NHS Foundation Trust, Liverpool, Merseyside, United KingdomDepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha, ChinaIntroductionMultiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization. This study aims to evaluate the impact of MDR Gram-negative bacteraemia on IPN patients.MethodsA case–control study was performed with data collected from 1 January 2016 to 1 July 2022 in a Chinese tertiary teaching hospital. Clinical data of the IPN patients with MDR-GNB bacteraemia were analyzed and compared to those of a matched control group without MDR-GNB bacteraemia (case–control ratio of 1:2). Comparisons were performed between with/without MDR-GNB bacteraemia and different severities of acute pancreatitis (AP). Independent predictors of overall mortality were identified via univariate and multivariate binary logistic regression analyses.ResultsMDR-GNB bacteraemia was related to a higher mortality rate (62.5% vs. 8.3%, p < 0.001). Severe AP combined with MDR-GNB bacteraemia further increased mortality up to 81.3% (p = 0.025). MDR-GNB bacteraemia (odds ratio (OR) = 8.976, 95% confidence interval (CI) = 1.805 –44.620, p = 0.007) and severe AP (OR = 9.414, 95% CI = 1.742 –50.873, p = 0.009) were independent predictors of overall mortality. MDR- Klebsiella pneumoniae was the most common causative pathogen.ConclusionA higher mortality rate in IPN patients was related to MDR-GNB bacteraemia and further increased in severe AP patients combined with MDR-GNB bacteraemia.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1044188/fullmultiple drug-resistantGram-negative bacterial bacteraemiainfected pancreatic necrosisacute pancreatitismortality |
| spellingShingle | Di Wu Di Wu Yan Jia Wenhao Cai Wenhao Cai Yilin Huang Arjun Kattakayam Diane Latawiec Robert Sutton Jie Peng Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients Frontiers in Cellular and Infection Microbiology multiple drug-resistant Gram-negative bacterial bacteraemia infected pancreatic necrosis acute pancreatitis mortality |
| title | Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients |
| title_full | Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients |
| title_fullStr | Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients |
| title_full_unstemmed | Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients |
| title_short | Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients |
| title_sort | impact of multiple drug resistant gram negative bacterial bacteraemia on infected pancreatic necrosis patients |
| topic | multiple drug-resistant Gram-negative bacterial bacteraemia infected pancreatic necrosis acute pancreatitis mortality |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1044188/full |
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