NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/6/904 |
| _version_ | 1797565352722300928 |
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| author | Ángel Cores Marta Piquero Mercedes Villacampa Rafael León J. Carlos Menéndez |
| author_facet | Ángel Cores Marta Piquero Mercedes Villacampa Rafael León J. Carlos Menéndez |
| author_sort | Ángel Cores |
| collection | DOAJ |
| description | NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases. |
| first_indexed | 2024-03-10T19:10:57Z |
| format | Article |
| id | doaj.art-3878ea556d434e2bb233d058ca8f4006 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T19:10:57Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3878ea556d434e2bb233d058ca8f40062023-11-20T03:47:37ZengMDPI AGBiomolecules2218-273X2020-06-0110690410.3390/biom10060904NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative DiseasesÁngel Cores0Marta Piquero1Mercedes Villacampa2Rafael León3J. Carlos Menéndez4Unidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, SpainUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, SpainUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, SpainInstituto Teófilo Hernando y Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, SpainUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, SpainNRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.https://www.mdpi.com/2218-273X/10/6/904NRF2–ARE pathwayneurodegenerative diseasesoxidative stressKEAP1NRF2 regulation |
| spellingShingle | Ángel Cores Marta Piquero Mercedes Villacampa Rafael León J. Carlos Menéndez NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases Biomolecules NRF2–ARE pathway neurodegenerative diseases oxidative stress KEAP1 NRF2 regulation |
| title | NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases |
| title_full | NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases |
| title_fullStr | NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases |
| title_full_unstemmed | NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases |
| title_short | NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases |
| title_sort | nrf2 regulation processes as a source of potential drug targets against neurodegenerative diseases |
| topic | NRF2–ARE pathway neurodegenerative diseases oxidative stress KEAP1 NRF2 regulation |
| url | https://www.mdpi.com/2218-273X/10/6/904 |
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